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1G244
🥰Excellent
Catalog No. T14005Cas No. 847928-32-9
1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki values for 1G244 were 0.9 and 4.2 nM for DPP8 and DPP9
1G244
🥰Excellent
Purity: 98.23%
Catalog No. T14005Cas No. 847928-32-9
1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki values for 1G244 were 0.9 and 4.2 nM for DPP8 and DPP9
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $33 | In Stock | |
| 10 mg | $53 | In Stock | |
| 25 mg | $106 | In Stock | |
| 50 mg | $173 | In Stock | |
| 100 mg | $283 | In Stock | |
| 500 mg | Inquiry | In Stock |
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Purity:98.23%
ee:98.76%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki values for 1G244 were 0.9 and 4.2 nM for DPP8 and DPP9 |
| Targets&IC50 | DPP9:4.2 nM(ki), DPP9:53 nM, DPP8:14 nM, DPP8:0.9 nM(ki) |
| In vitro | 1G244 (0-100 μM) dose-dependently decreased viable cell number of five multiple myeloma cell lines as well as three T-cell lymphoma cell lines[2]. |
| In vivo | The apoE−/− mice treated with 1G244 (1G244 dissolved in 75% PEG 300, 2 mg/kg) showed that 1G244 reduced the area of advanced atherosclerotic lesions by about 14%[1]. 1G244 was administered subcutaneously into mice at 30 mg/kg once a week, administration of 1G244 apparently suppressed the subcutaneous growth of MM.1 S cells[2]. |
| Molecular Weight | 504.57 |
| Formula | C29H30F2N4O2 |
| Cas No. | 847928-32-9 |
| Smiles | N[C@@H](CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1Cc2ccccc2C1 |
| Relative Density. | 1.304 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 225.0 mg/mL (445.9 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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