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3-Amino-1,2,4-triazole

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Purity:97.16%

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COA HNMR HPLC

3-Amino-1,2,4-triazole

Catalog No. T67498Cas No. 61-82-5

3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase.

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10 g	$41	In Stock

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Product Introduction

Bioactivity

Description	3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase.
In vitro	3-Amino-1,2,4-triazole (10 mM; 24h) treatment decreased CAT activity and increased intracellular H2O2 levels significantly. Glutathione peroxidase (GPX) activity was also reduced, and the gene expression levels of the antioxidant enzymes GPX4 and peroxiredoxins were inhibited.[5]
Alias	Amitrole, 3-AT, 1H-1,2,4-Triazol-5-amine, Trapidil impurity B

Chemical Properties

Molecular Weight	84.08
Formula	C2H4N4
Cas No.	61-82-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (1070.4 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	11.8934 mL	59.4672 mL	118.9343 mL	594.6717 mL
5 mM	2.3787 mL	11.8934 mL	23.7869 mL	118.9343 mL
10 mM	1.1893 mL	5.9467 mL	11.8934 mL	59.4672 mL
20 mM	0.5947 mL	2.9734 mL	5.9467 mL	29.7336 mL
50 mM	0.2379 mL	1.1893 mL	2.3787 mL	11.8934 mL
100 mM	0.1189 mL	0.5947 mL	1.1893 mL	5.9467 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc