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3-Amino-1,2,4-triazole
Catalog No. T67498Cas No. 61-82-5
Alias Trapidil impurity B, Amitrole, 3-AT, 1H-1,2,4-Triazol-5-amine
3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase.
3-Amino-1,2,4-triazole
Catalog No. T67498Alias Trapidil impurity B, Amitrole, 3-AT, 1H-1,2,4-Triazol-5-amineCas No. 61-82-5
3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 g | $41 | In Stock |
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Purity:97.16%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase. |
| In vitro | 3-Amino-1,2,4-triazole (1,10 and 100 microg/ml ) had no significant cytotoxicity to the FRTL-5 cells (P > 0.05). The concentration of thyroglobulin (TG) in the culture was decreased by 10 and 100 microg/ml 3-Amino-1,2,4-triazole (P < 0.05), and the concentration of TG in the cells was decreased by 100 microg/ml (P < 0.05) but the TTF-1 in the cells were not obviously changed (P > 0.05). The TSHR in the surface of FRTL-5 cells was significantly decreased by all doses of 3-Amino-1,2,4-triazole (P < 0.01). The influence of 3-Amino-1,2,4-triazole on TG of FRTL-5 cells may be related to significantly reduce TSHR in the surface of FRTL-5 cells.[1] |
| Alias | Trapidil impurity B, Amitrole, 3-AT, 1H-1,2,4-Triazol-5-amine |
| Molecular Weight | 84.08 |
| Formula | C2H4N4 |
| Cas No. | 61-82-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (1070.4 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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