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Orotic acid monohydrate is an intermediate product in pyrimidine metabolism.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 g | $29 | In Stock |
Description | Orotic acid monohydrate is an intermediate product in pyrimidine metabolism. |
In vitro | Orotic acid increases cell proliferation and decreases apoptosis in serum-starved SK-Hep1 hepatocellular carcinoma cells, which may ascribe to the inhibition of AMP-activated protein kinase (AMPK) phosphorylation and thus activation of mammalian target of rapamycin complex 1 (mTORC1) [1]. |
In vivo | Male Fischer 344 rats (130-150 g) to two-thirds PH in the absence or in the presence of Orotic acid (a 300-mg tablet of Orotic acid methyl ester implanted intraperitoneally at the time of two-thirds PH). treatment with Orotic acid resulted in a near-100% inhibition of RNR induced by two-thirds PH in rat liver, as monitored by enzyme activity and protein level [2]. Feeding 1% Orotic acid with diet decreased the phosphorylation of AMPK and increased the maturation of SREBP-1 and the expression of SREBP-responsive genes in the rat liver. Orotic acid-induced lipid accumulation was also completely inhibited by rapamycin. Mouse hepatocytes and mice were resistant to Orotic acid-induced lipogenesis because of little if any response in AMPK and downstream effectors [3]. |
Alias | Orotic Acid Monohydrate, 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate, 2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate |
Molecular Weight | 174.11 |
Formula | C5H6N2O5 |
Cas No. | 50887-69-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 2.5 mg/mL (14.36 mM), Sonication is recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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