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Orotic acid monohydrate

Catalog No. T5078Cas No. 50887-69-9
Alias Orotic Acid Monohydrate, 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate, 2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate

Orotic acid monohydrate is an intermediate product in pyrimidine metabolism.

Orotic acid monohydrate

Orotic acid monohydrate

Purity: 100%
Catalog No. T5078Alias Orotic Acid Monohydrate, 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate, 2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrateCas No. 50887-69-9
Orotic acid monohydrate is an intermediate product in pyrimidine metabolism.
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5 g$29In Stock
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Product Introduction

Bioactivity
Description
Orotic acid monohydrate is an intermediate product in pyrimidine metabolism.
In vitro
Orotic acid increases cell proliferation and decreases apoptosis in serum-starved SK-Hep1 hepatocellular carcinoma cells, which may ascribe to the inhibition of AMP-activated protein kinase (AMPK) phosphorylation and thus activation of mammalian target of rapamycin complex 1 (mTORC1) [1].
In vivo
Male Fischer 344 rats (130-150 g) to two-thirds PH in the absence or in the presence of Orotic acid (a 300-mg tablet of Orotic acid methyl ester implanted intraperitoneally at the time of two-thirds PH). treatment with Orotic acid resulted in a near-100% inhibition of RNR induced by two-thirds PH in rat liver, as monitored by enzyme activity and protein level [2]. Feeding 1% Orotic acid with diet decreased the phosphorylation of AMPK and increased the maturation of SREBP-1 and the expression of SREBP-responsive genes in the rat liver. Orotic acid-induced lipid accumulation was also completely inhibited by rapamycin. Mouse hepatocytes and mice were resistant to Orotic acid-induced lipogenesis because of little if any response in AMPK and downstream effectors [3].
AliasOrotic Acid Monohydrate, 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate, 2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate
Chemical Properties
Molecular Weight174.11
FormulaC5H6N2O5
Cas No.50887-69-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 2.5 mg/mL (14.36 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.7435 mL28.7175 mL57.4350 mL287.1748 mL
5 mM1.1487 mL5.7435 mL11.4870 mL57.4350 mL
10 mM0.5743 mL2.8717 mL5.7435 mL28.7175 mL

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