Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor. It affects the intercellular messenger NO synthesis throughout the brain and body.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 70.00 | |
50 mg | In stock | $ 122.00 | |
100 mg | In stock | $ 198.00 | |
200 mg | In stock | $ 297.00 | |
500 mg | In stock | $ 511.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | 3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor. It affects the intercellular messenger NO synthesis throughout the brain and body. |
In vivo | Male rats received either 3-Bromo-7-nitroindazole (20mg/kg/day) or saline via intraperitoneal injection for 5days. Daily administration of the specific neuronal nitric oxide synthase (nNOS) inhibitor, 3-Bromo-7-nitroindazole impaired the acquisition of the Morris water maze (MWM) paradigm task. 3-Bromo-7-nitroindazole also impaired the probe trial. The MWM training was associated with a significant increase in the brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus. BDNF mRNA expression in the hippocampus did not change after 3-Bromo-7-nitroindazole treatment. L-arginine significantly reversed behavioural parameters, and the effect of 3-Bromo-7-nitroindazole was found to be NO-dependent. There were no differences in locomotor activity and blood pressure in 3-Bromo-7-nitroindazole treated rats[1]. |
Molecular Weight | 242.03 |
Formula | C7H4BrN3O2 |
CAS No. | 74209-34-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (413.17 mM)
You can also refer to dose conversion for different animals. More
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3-Bromo-7-nitroindazole 74209-34-0 Immunology/Inflammation NOS 3Bromo7nitroindazole inhibit NO Synthase Nitric oxide synthases Inhibitor 3 Bromo 7 nitroindazole inhibitor