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5-O-Caffeoylshikimic acid

Catalog No. TN1295 CAS 73263-62-4

5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.

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5-O-Caffeoylshikimic acid Chemical Structure

5-O-Caffeoylshikimic acid, CAS 73263-62-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 116.00
5 mg	In stock	$ 282.00
10 mg	In stock	$ 418.00
25 mg	In stock	$ 695.00
50 mg	In stock	$ 988.00
1 mL * 10 mM (in DMSO)	In stock	$ 370.00

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Purity: 99.82%

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Description	5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.
In vitro	Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line.Methylprototribestin, structurally related compounds and a mixture of 3 acetylated isomers of methylprotodioscin were investigated for antiproliferative effect and modulation of drug accumulation. RESULTS: The growth inhibitory dose (ID50) of the compounds ranged from 12.64 to 20.62 mug/ml. Methylprototribestin was the most effective resistance modifier. However, methylprotodioscin, pseudoprotodioscin, prosapogenin A of dioscin, tribestin and 5-O-Caffeoylshikimic acid showed moderate MDR reversal activity. In a checkerboard method, methyloprototribestin and the mixture of the 3 acetylated isomers enhanced the antiproliferative effects on MDR cells in combination with doxorubicin. CONCLUSION: Based on these results, methylprototribestin and the mixture of the 3 acetylated isomers can be recommended for further in vivo experiments in combination with anthracyclines in human MDR-cancer xenograft transplanted mice[1]
Source	Natural Products > Illiciaceae > Illicium

Molecular Weight	336.29
Formula	C16H16O8
CAS No.	73263-62-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (148.68 mM)

References and Literature

1. Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators.In Vivo. 2009 Jul-Aug;23(4):545-50.

Related compound libraries

This product is contained In the following compound libraries：

Chinese Pharmacopoeia Natural Product Library Bioactive Compounds Library Max RO5 Drug-like Natural Product Library Bioactive Compound Library Food as Medicine Compound Library Anti-Tumor Natural Product Library Natural Product Library for HTS NF-κB Signaling Compound Library Traditional Chinese Medicine Monomer Library Traditional Mongolian Medicine Compound Library

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Keywords

5-O-Caffeoylshikimic acid 73263-62-4 Apoptosis Immunology/Inflammation TNF IL Receptor NO Synthase inhibit 5 O Caffeoylshikimic acid Inhibitor 5OCaffeoylshikimic acid inhibitor

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