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5J-4

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Purity:96.12%

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COA HNMR HPLC

5J-4

Catalog No. T24984Cas No. 827001-82-1

5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.

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Pack Size	Price	Availability
5 mg	$98	In Stock
10 mg	$154	In Stock
25 mg	$263	In Stock
50 mg	$395	In Stock
1 mL x 10 mM (in DMSO)	$111	In Stock

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Product Introduction

Bioactivity

Description

In vivo

5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of the infiltrated mononuclear cell in the CNS, and significantly decreased the population of infiltrated CD4+ population. 5J-4 reduced the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in the mouse model of inflammation[1].

Chemical Properties

Molecular Weight	312.34
Formula	C16H12N2O3S
Cas No.	827001-82-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (160.08 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2016 mL	16.0082 mL	32.0164 mL	160.0820 mL
5 mM	0.6403 mL	3.2016 mL	6.4033 mL	32.0164 mL
10 mM	0.3202 mL	1.6008 mL	3.2016 mL	16.0082 mL
20 mM	0.1601 mL	0.8004 mL	1.6008 mL	8.0041 mL
50 mM	0.0640 mL	0.3202 mL	0.6403 mL	3.2016 mL
100 mM	0.0320 mL	0.1601 mL	0.3202 mL	1.6008 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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