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7,4'-Dihydroxyflavone

Catalog No. TN1273 CAS 2196-14-7

Synonyms: Inhibitor, 7,4'Dihydroxyflavone, inhibit, Nuclear factor-κB, NF-κB, 4',7-Dihydroxyflavone, CCR, Nuclear factor-kappaB, 7,4'-Dihydroxyflavone, 7,4' Dihydroxyflavone, CC chemokine receptor

4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.

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7,4'-Dihydroxyflavone, CAS 2196-14-7

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Purity: 98%

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Description	4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
Targets&IC50	NCI-H292 human airway epithelial cell) (7,4'-Dihydroxyflavone:1.4 μM (NCI-H292 human airway epithelial cell) (IC50)
In vitro	Root exudate from 3-day-old alfalfa seedlings was purified and then assayed for biological activity with a nodABC-lacZ fusion in R. meliloti. Indentities of major nod inducers were established by spectroscopic analyses (ultraviolet/visible, proton nuclear magnetic resonance, and mass spectroscopy) and comparison with authentic standards. Major nod inducers, which were identified as 4',7-Dihydroxyflavone, 4'-7-dihydroxyflavanone, and 4,4'-dihydroxy-2'-methoxychalcone, were released from seedling roots at 54, 22, and 20 picomole.plant(-1).day(-1), respectively. Luteolin was not found in these root exudates.

Synonyms	Inhibitor, 7,4'Dihydroxyflavone, inhibit, Nuclear factor-κB, NF-κB, 4',7-Dihydroxyflavone, CCR, Nuclear factor-kappaB, 7,4'-Dihydroxyflavone, 7,4' Dihydroxyflavone, CC chemokine receptor
Molecular Weight	254.24
Formula	C15H10O4
CAS No.	2196-14-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 250 mg/mL (983.32 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. A Chalcone and Two Related Flavonoids Released from Alfalfa Roots Induce nod Genes of Rhizobium meliloti.Plant Physiol., 1989, 91(3):842-7.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Inhibitor Library Immunology/Inflammation Compound Library Rare Natural Compound Library Anti-Aging Compound Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.