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7-Chlorokynurenic acid
🥰Excellent
Catalog No. T10191LCas No. 18000-24-3
Alias 7-CKA, 7-chloro-4-hydroxy-2-carboxyquinoline
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.
7-Chlorokynurenic acid
🥰Excellent
Purity: 99.72%
Catalog No. T10191LAlias 7-CKA, 7-chloro-4-hydroxy-2-carboxyquinolineCas No. 18000-24-3
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $38 | In Stock | |
| 10 mg | $61 | In Stock | |
| 25 mg | $128 | In Stock | |
| 50 mg | $245 | In Stock | |
| 100 mg | $473 | In Stock | |
| 500 mg | $987 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $67 | In Stock |
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Purity:99.72%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery. |
| Targets&IC50 | Glycine B coagonist site of NMDA receptor:0.56 μM(ki), Reuptake of glutamate:（ki）0.59 μM |
| In vivo | In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response[3]. |
| Alias | 7-CKA, 7-chloro-4-hydroxy-2-carboxyquinoline |
| Molecular Weight | 223.61 |
| Formula | C10H6ClNO3 |
| Cas No. | 18000-24-3 |
| Smiles | OC(=O)c1cc(O)c2ccc(Cl)cc2n1 |
| Relative Density. | 1.549 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 15 mg/mL (67.1 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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