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84-B10 protects against cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors, inhibiting mitochondrial damage and mtROS production, and restoring superoxide dismutase to reduce cisplatin-induced kidney damage.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
5 mg | $98 | In Stock | |
10 mg | $172 | In Stock | |
25 mg | $338 | In Stock | |
50 mg | $519 | In Stock | |
100 mg | $782 | In Stock | |
200 mg | $1,060 | In Stock | |
1 mL x 10 mM (in DMSO) | $107 | In Stock |
Description | 84-B10 protects against cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors, inhibiting mitochondrial damage and mtROS production, and restoring superoxide dismutase to reduce cisplatin-induced kidney damage. |
In vitro | 84-B10 (10-100 μM,2 h) inhibited cisplatin induced iron death in renal tubular epithelial cells in a dose-dependent manner. Treatment with 84-B10 (40 μM, 2 hours) restored cisplatin induced mitochondrial structural damage and dysfunction. 84-B10 (40 μM, 2 hours) mitigated MTROS-induced oxidative stress in cisplatin-induced AKI. 84-B10 (40 μM, 2 hours) alleviates cisplatin induced epithelial cell damage by eliminating mtROS and restoring mitochondrial homeostasis [1]. |
In vivo | 84-B10 plays a protective role in cisplatin induced acute kidney injury, but has no tumor-promoting effect. [1] |
Molecular Weight | 473.44 |
Formula | C25H22F3NO5 |
Cas No. | 698346-43-9 |
Smiles | O=C(O)CC(C=1C=CC=CC1)CC(=O)NC2=CC(=CC=C2OC3=CC=C(OC)C=C3)C(F)(F)F |
Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 0.1 mg/mL (insoluble) DMSO: 80 mg/mL (168.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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