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84-B10

🥰Excellent
Catalog No. T75268Cas No. 698346-43-9

84-B10 protects against cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors, inhibiting mitochondrial damage and mtROS production, and restoring superoxide dismutase to reduce cisplatin-induced kidney damage.

84-B10

84-B10

🥰Excellent
Purity: 99.76%
Catalog No. T75268Cas No. 698346-43-9
84-B10 protects against cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors, inhibiting mitochondrial damage and mtROS production, and restoring superoxide dismutase to reduce cisplatin-induced kidney damage.
Pack SizePriceAvailabilityQuantity
1 mg$44 In Stock
5 mg$98 In Stock
10 mg$172 In Stock
25 mg$338 In Stock
50 mg$519 In Stock
100 mg$782 In Stock
200 mg$1,060 In Stock
1 mL x 10 mM (in DMSO)$107 In Stock
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Purity:99.76%
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Product Introduction

Bioactivity
Description
84-B10 protects against cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors, inhibiting mitochondrial damage and mtROS production, and restoring superoxide dismutase to reduce cisplatin-induced kidney damage.
In vitro
84-B10 (10-100 μM,2 h) inhibited cisplatin induced iron death in renal tubular epithelial cells in a dose-dependent manner.
Treatment with 84-B10 (40 μM, 2 hours) restored cisplatin induced mitochondrial structural damage and dysfunction.
84-B10 (40 μM, 2 hours) mitigated MTROS-induced oxidative stress in cisplatin-induced AKI.
84-B10 (40 μM, 2 hours) alleviates cisplatin induced epithelial cell damage by eliminating mtROS and restoring mitochondrial homeostasis [1].
In vivo
84-B10 plays a protective role in cisplatin induced acute kidney injury, but has no tumor-promoting effect. [1]
Chemical Properties
Molecular Weight473.44
FormulaC25H22F3NO5
Cas No.698346-43-9
SmilesO=C(O)CC(C=1C=CC=CC1)CC(=O)NC2=CC(=CC=C2OC3=CC=C(OC)C=C3)C(F)(F)F
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
H2O: < 0.1 mg/mL (insoluble)
DMSO: 80 mg/mL (168.98 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1122 mL10.5610 mL21.1220 mL105.6100 mL
5 mM0.4224 mL2.1122 mL4.2244 mL21.1220 mL
10 mM0.2112 mL1.0561 mL2.1122 mL10.5610 mL
20 mM0.1056 mL0.5281 mL1.0561 mL5.2805 mL
50 mM0.0422 mL0.2112 mL0.4224 mL2.1122 mL
100 mM0.0211 mL0.1056 mL0.2112 mL1.0561 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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