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84-B10
🥰Excellent
Catalog No. T75268Cas No. 698346-43-9
84-B10 protects against cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors, inhibiting mitochondrial damage and mtROS production, and restoring superoxide dismutase to reduce cisplatin-induced kidney damage.
84-B10
🥰Excellent
Purity: 99.76%
Catalog No. T75268Cas No. 698346-43-9
84-B10 protects against cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors, inhibiting mitochondrial damage and mtROS production, and restoring superoxide dismutase to reduce cisplatin-induced kidney damage.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $44 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $172 | In Stock | |
| 25 mg | $338 | In Stock | |
| 50 mg | $519 | In Stock | |
| 100 mg | $782 | In Stock | |
| 200 mg | $1,060 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $107 | In Stock |
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Purity:99.76%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 84-B10 protects against cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors, inhibiting mitochondrial damage and mtROS production, and restoring superoxide dismutase to reduce cisplatin-induced kidney damage. |
| In vitro | 84-B10 (10-100 μM,2 h) inhibited cisplatin induced iron death in renal tubular epithelial cells in a dose-dependent manner. Treatment with 84-B10 (40 μM, 2 hours) restored cisplatin induced mitochondrial structural damage and dysfunction. 84-B10 (40 μM, 2 hours) mitigated MTROS-induced oxidative stress in cisplatin-induced AKI. 84-B10 (40 μM, 2 hours) alleviates cisplatin induced epithelial cell damage by eliminating mtROS and restoring mitochondrial homeostasis [1]. |
| In vivo | 84-B10 plays a protective role in cisplatin induced acute kidney injury, but has no tumor-promoting effect. [1] |
| Molecular Weight | 473.44 |
| Formula | C25H22F3NO5 |
| Cas No. | 698346-43-9 |
| Smiles | O=C(O)CC(C=1C=CC=CC1)CC(=O)NC2=CC(=CC=C2OC3=CC=C(OC)C=C3)C(F)(F)F |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 0.1 mg/mL (insoluble) DMSO: 80 mg/mL (168.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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