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AER-271

Catalog No. T7946 CAS 634913-39-6

AER-271 is an inhibitor of aquaporin-4.

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AER-271, CAS 634913-39-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AER-271 is an inhibitor of aquaporin-4.
In vivo	Treatment with AER-271 ameliorated early cerebral edema measured at 3 h after CA vs vehicle treated rats. This treatment also attenuated early NDS. In contrast to rats treated with vehicle after CA, rats treated with AER-271 did not develop significant neuronal death or neuroinflammation as compared to sham.

Molecular Weight	463.65
Formula	C15H9ClF6NO5P
CAS No.	634913-39-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 27.5 mg/mL (59.31 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wallisch J S , Janesko-Feldman K , Alexander H , et al. The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest[J]. Pediatric research, 2019, 85.

Dose Conversion

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AER-271 634913-39-6 Membrane transporter/Ion channel Aquaporin Inhibitor AQP4 AER-270 stroke inhibit aquaporin-4 injury AER 271 acute AER271 CNS ischemic inhibitor

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