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AM-2394

Catalog No. T3312 CAS 1442684-77-6

Synonyms: AM2394

AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.

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AM-2394, CAS 1442684-77-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 347.00
100 mg	In stock	$ 538.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.62%

Purity: 99.58%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.
Targets&IC50	GKA:60 nM(EC50)
In vivo	AM-2394, a novel glucokinase activator, prominently reduces plasma glucose levels in ob/ob mice during an oral glucose tolerance test (OGTT) at a 3 mg/kg dosage. It enhances glucokinase's (GK) glucose affinity by roughly 10-fold, showing moderate clearance and favorable oral bioavailability across various animal models. Additionally, AM-2394 significantly improves glucose control following an OGTT in an ob/ob mouse model of diabetes. It demonstrates suitable cross-species plasma clearance, distribution volume, and oral bioavailability, supporting its potential for further investigation in animal studies[1].
Kinase Assay	Kinase screen: Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol).

Synonyms	AM2394
Molecular Weight	423.46
Formula	C22H25N5O4
CAS No.	1442684-77-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (118.15 mM)

References and Literature

1. Dransfield PJ, et al. Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett. 2016 May 23;7(7):714-8.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Metabolism Compound Library Target-Focused Phenotypic Screening Library Metabolism Compound Library Bioactive Compound Library Kinase Inhibitor Library Anti-Metabolism Disease Compound Library Glycometabolism Compound Library NO PAINS Compound Library Anti-Diabetic Compound Library Glycolysis Compound Library

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Keywords

AM-2394 1442684-77-6 Metabolism Glucokinase Hexokinase D Inhibitor AM 2394 AM2394 inhibit Hexokinase IV inhibitor

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