Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 40.00 | |
2 mg | In stock | $ 57.00 | |
5 mg | In stock | $ 85.00 | |
10 mg | In stock | $ 133.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 393.00 | |
100 mg | In stock | $ 571.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo. |
In vivo | ASP7663, a novel and selective TRPA1 agonist, in constipation models as well as an abdominal pain model.?ASP7663 activated human, rat, and mouse TRPA1 and released 5-HT from QGP-1 cells, and oral but not intravenous administration of ASP7663 significantly improved the loperamide-induced delay in colonic transit in mice.?While pretreatment with the TRPA1 antagonist HC-030031 and vagotomy both inhibited the ameliorating effect of oral ASP7663 on the colonic transit, both orally and intravenously administered ASP7663 significantly inhibited colorectal distension (CRD)-induced abdominal pain response in rats[1]. |
Molecular Weight | 263.26 |
Formula | C14H14FNO3 |
CAS No. | 1190217-35-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (41.78 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ASP7663 1190217-35-6 Membrane transporter/Ion channel TRP/TRPV Channel pain inhibit TRP Channel Transient receptor potential channels Inhibitor ASP 7663 ASP-7663 inhibitor