Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AU1235 is a Mycobacterium tuberculosis inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 68.00 | |
2 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 308.00 | |
25 mg | In stock | $ 519.00 | |
50 mg | In stock | $ 753.00 | |
100 mg | In stock | $ 1,060.00 | |
500 mg | In stock | $ 2,120.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 177.00 |
Description | AU1235 is a Mycobacterium tuberculosis inhibitor. |
In vitro | AU1235 has a MIC of 0.1 μg/mL (0.3 μM) (minimum bactericidal concentration of 0.1 μg/mL. AU1235 is similarly active against MDR clinical isolates of M. tb displaying resistance to isoniazid, rifampicin, and pyrazinamide in addition to streptomycin, fluoroquinolones and/or ethambutol. AU1235 also inhibits Mycobacterium smegmatis and Mycobacterium fortuitum (MICs: 3.2 to 6.4 μg/mL). AU1235 (10 times MIC) does not increase the killing effect within the first 7 days indicating that the killing is time-dependent rather than concentration-dependent. In an anaerobic model involving non-replicating M. tb H37Rv bacilli, AU1235 at 10 μg/mL shows no detectable activity suggesting that it acts on a biosynthetic pathway required for active bacterial multiplication. AU1235 does not inhibit the biosynthesis of mycolic acids per se but specifically their ability to be transferred onto their cell wall and outer membrane acceptors. |
Molecular Weight | 324.34 |
Formula | C17H19F3N2O |
CAS No. | 1338780-86-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 24 mg/mL (74 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AU1235 1338780-86-1 Microbiology/Virology Antibacterial Inhibitor MmpL3 transport AU 1235 tuberculosis cell AU-1235 synthesis inhibit Bacterial wall Mycobacterium inhibitor