AVE5688

AVE5688, an inhibitor of glycogen phosphorylase (GP), has IC50 values of 430 nM and 915 nM, and Kd values of 170 nM and 530 nM for rmGPb and rmGPa, respectively. It is suitable for research on type 2 diabetes.

Catalog No. T10421Cas No. 613260-13-2

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Purity:100%

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COA HPLC HNMR

AVE5688

Catalog No. T10421Cas No. 613260-13-2

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Pack Size	Price	Availability
1 mg	$282	In Stock
5 mg	$448	In Stock
10 mg	$630	In Stock
25 mg	$936	In Stock
50 mg	$1,240	In Stock
100 mg	$1,690	In Stock
1 mL x 10 mM (in DMSO)	$583	In Stock

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Product Introduction

Bioactivity

Description	AVE5688, an inhibitor of glycogen phosphorylase (GP), has IC50 values of 430 nM and 915 nM, and Kd values of 170 nM and 530 nM for rmGPb and rmGPa, respectively. It is suitable for research on type 2 diabetes.
Targets&IC50	GPa (rabbit muscle):530 nM , GPa (rabbit muscle):915 nM , GPb (rabbit muscle):(kd)170 nM , GPb (rabbit muscle):430 nM

Chemical Properties

Molecular Weight	438.69
Formula	C₁₆H₈ClF₅N₂O₅
Cas No.	613260-13-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (125.37 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2795 mL	11.3976 mL	22.7951 mL	113.9757 mL
5 mM	0.4559 mL	2.2795 mL	4.5590 mL	22.7951 mL
10 mM	0.2280 mL	1.1398 mL	2.2795 mL	11.3976 mL
20 mM	0.1140 mL	0.5699 mL	1.1398 mL	5.6988 mL
50 mM	0.0456 mL	0.2280 mL	0.4559 mL	2.2795 mL
100 mM	0.0228 mL	0.1140 mL	0.2280 mL	1.1398 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc