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AZ-5104

Catalog No. T2491 CAS 1421373-98-9

AZ5104 is a potent EGFR inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AZ-5104, CAS 1421373-98-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 48.00
10 mg	In stock	$ 68.00
25 mg	In stock	$ 125.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 265.00
200 mg	In stock	$ 333.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 99.9%

Purity: 99.59%

Purity: 98.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AZ5104 is a potent EGFR inhibitor.
Targets&IC50	EGFR (L861Q):1 nM, EGFR (L858R):6 nM, ERB4:7 nM, EGFR (WT):25 nM, EGFR (L858R/T790M):<1 nM
In vitro	AZ5104 shows great potency against ex19del (2 nM in PC-9), T790M (2 nM in H1975), and wild-type EGFR (33 nM in LOVO) cell lines. AZ5104 causes inhibition of cell viability with IC50 of 3.3 nM, 2.6 nM, 80 nM, and 53 nM for H1975 (T790M/L858R), PC-9 (ex19del), Calu 3 (WT), and NCI-H2073 (WT), respectively. [1]
In vivo	In both C/L858R and C/L+T mice, AZ5104 (5 mg/kg/d, p.o.) induces significant and sustained tumor regression. [1]
Kinase Assay	Recombinant Kinase assays: Kinase assays are performed using peptide or protein substrates in a filter-binding radioactive ATP transferase assay for protein kinases, or lipid substrates and HTRF assay for lipid kinase.

Molecular Weight	485.58
Formula	C27H31N7O2
CAS No.	1421373-98-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 16 mg/mL(33 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 90 mg/mL (185.3 mM)

References and Literature

1. Cross DA, et al. Cancer Discov. 2014, 4(9), 1046-1061.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Membrane Protein-targeted Compound Library Kinase Inhibitor Library Cysteine Covalent Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Anti-Colorectal Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Breast Cancer Compound Library

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Related compounds with same targets

EAI045 Ligustroside EGFR/BRAFV600E-IN-3 Patritumab JCN037 Tyrphostin AG 112 EGFR mutant-IN-1 PD153035 hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AZ-5104 1421373-98-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR AZ 5104 Epidermal growth factor receptor HER1 ErbB-1 inhibit AZ5104 Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.