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AZD8931 diFuMaric acid

AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).

Catalog No. T8751Cas No. 1196531-39-1

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Purity:99%

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COA HNMR HPLC

AZD8931 diFuMaric acid

Catalog No. T8751Cas No. 1196531-39-1

AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$181	In Stock
10 mg	$272	In Stock
25 mg	$448	In Stock
50 mg	$630	In Stock
100 mg	$852	In Stock
200 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$269	In Stock

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Product Introduction

Bioactivity

Description	AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).
Targets&IC50	ERB3:4 nM, ErbB2:3 nM , EGFR:4 nM
In vivo	AZD8931 significantly suppressed cell growth of IBC cells and induced apoptosis of human IBC cells in vitro.AZD8931 monotherapy inhibited xenograft growth[1].
Animal Research	Two IBC cell lines SUM149 and FC-IBC-02 。Cell growth and apoptotic cell death were examined in vitro.?For the in vivo tumor growth studies, IBC cells were orthotopically transplanted into the mammary fat pads of immunodeficient mice.?AZD8931 was given by daily oral gavage at doses of 25 mg/kg, 5 days/week for 4 weeks.?Paclitaxel was subcutaneously injected twice weekly[1].

Chemical Properties

Molecular Weight	706.1
Formula	C₃₁H₃₃ClFN₅O₁₁
Cas No.	1196531-39-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (42.49 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4162 mL	7.0811 mL	14.1623 mL	70.8115 mL
5 mM	0.2832 mL	1.4162 mL	2.8325 mL	14.1623 mL
10 mM	0.1416 mL	0.7081 mL	1.4162 mL	7.0811 mL
20 mM	0.0708 mL	0.3541 mL	0.7081 mL	3.5406 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc