Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 163.00 | |
50 mg | In stock | $ 263.00 | |
100 mg | In stock | $ 422.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit. |
Targets&IC50 | FLT3:7 nM, c-Kit:9 nM, PDGFRβ:4 nM, VEGFR2:8 nM |
In vitro | In the C6 rat glioma model, oral administration of AZD2932 (12.5 or 50 mg/kg, b.i.d.) was able to inhibit tumor growth. Additionally, in xenografts with tumors not expressing PDGFβ, oral doses of AZD2932 (50 mg/kg, b.i.d.) succeeded in suppressing the growth of Calu-6 and LoVo tumors. |
In vivo | AZD2932 effectively inhibits the phosphorylation of PDGFRα and PDGFRβ, demonstrating strong activity against a variety of receptors including VEGFR-2 (IC50=8 nM), PDGFRβ (IC50=4 nM), Flt-3 (IC50=7 nM), and c-Kit (IC50=9 nM). |
Kinase Assay | Kinase Assays : In vitro kinase IC50 values are measured using 33P filtration binding assay after 1 hour incubation of kinase, 33P-ATP, Ibrutinib, and substrate [0.2 mg/mL poly(EY)(4:1]. Assays are performed at Reaction Biology. |
Molecular Weight | 447.49 |
Formula | C24H25N5O4 |
CAS No. | 883986-34-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 82 mg/mL (183.2 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 5 mg/mL (11.17 mM), Heating is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AZD2932 883986-34-3 Angiogenesis Tyrosine Kinase/Adaptors c-Kit PDGFR VEGFR FLT Platelet-derived growth factor receptor Inhibitor Fms like tyrosine kinase 3 Cluster of differentiation antigen 135 Vascular endothelial growth factor receptor FLT3 SCFR inhibit CD117 AZD 2932 AZD-2932 CD135 inhibitor