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Afzelin

Catalog No. TN1362 CAS 482-39-3

Synonyms: Kaempferol-3-O-rhamnoside

Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced damage by a combination of UV-absorbing and cellular activities. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1.

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Afzelin, CAS 482-39-3

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Purity: 99.38%

Biological Description

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Storage & Solubility Information

Description	Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced damage by a combination of UV-absorbing and cellular activities. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1.
In vitro	Therefore, in this study, we investigated the protective effects of Afzelin, one of the flavonoids, against UV irradiation in human keratinocytes and epidermal equivalent models. Spectrophotometric measurements revealed that the Afzelin extinction maxima were in the UVB and UVA range, and UV transmission below 376 nm was <10%, indicating UV-absorbing activity of Afzelin. In the phototoxicity assay using the 3T3 NRU phototoxicity test (3T3-NRU-PT), Afzelin presented a tendency to no phototoxic potential. In addition, in order to investigate cellular functions of Afzelin itself, cells were treated with Afzelin after UVB irradiation. In human keratinocyte, Afzelin effectively inhibited the UVB-mediated increase in lipid peroxidation and the formation of cyclobutane pyrimidine dimers. Afzelin also inhibited UVB-induced cell death in human keratinocytes by inhibiting intrinsic apoptotic signaling. Furthermore, Afzelin showed inhibitory effects on UVB-induced release of pro-inflammatory mediators such as interleukin-6, tumor necrosis factor-α±, and prostaglandin-E2 in human keratinocytes by interfering with the p38 kinase pathway. Using an epidermal equivalent model exposed to UVB radiation, anti-apoptotic activity of Afzelin was also confirmed together with a photoprotective effect at the morphological level[1]
Source	Natural Products > Santalaceae > Thesium

Synonyms	Kaempferol-3-O-rhamnoside
Molecular Weight	432.38
Formula	C21H20O10
CAS No.	482-39-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 12 mg/mL (27.75 mM), Sonification is recommended.

References and Literature

1. Shin SW, et al. Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage. PLoS One. 2013 Apr 23;8(4):e61971. 2. Lee SB, et al. Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. Br J Pharmacol. 2017 Jan;174(2):195-209.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Kinase Inhibitor Library GPCR Compound Library PBCRBS Traditional Chinese Medicine Compound Library Anti-Liver Cancer Compound Library Polyphenolic Natural Product Library Natural Product Library Bioactive Compound Library Anti-Cancer Compound Library Anti-Obesity Compound Library

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Keywords

Afzelin 482-39-3 Apoptosis Autophagy GPCR/G Protein Immunology/Inflammation MAPK Metabolism Microbiology/Virology PI3K/Akt/mTOR signaling PTEN TNF p38 MAPK Antibacterial Mitochondrial Metabolism Prostaglandin Receptor MMAC1 Phosphatase and tensin homolog inhibit Kaempferol-3-O-rhamnoside Inhibitor Bacterial inhibitor

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