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Afzelin

Catalog No. TN1362 CAS 482-39-3

Synonyms: 阿福豆苷, Kaempferol-3-O-rhamnoside

Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced damage by a combination of UV-absorbing and cellular activities. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1.

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Afzelin, CAS 482-39-3

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Purity: 98%

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Description

In vitro

Therefore, in this study, we investigated the protective effects of Afzelin, one of the flavonoids, against UV irradiation in human keratinocytes and epidermal equivalent models. Spectrophotometric measurements revealed that the Afzelin extinction maxima were in the UVB and UVA range, and UV transmission below 376 nm was <10%, indicating UV-absorbing activity of Afzelin. In the phototoxicity assay using the 3T3 NRU phototoxicity test (3T3-NRU-PT), Afzelin presented a tendency to no phototoxic potential. In addition, in order to investigate cellular functions of Afzelin itself, cells were treated with Afzelin after UVB irradiation. In human keratinocyte, Afzelin effectively inhibited the UVB-mediated increase in lipid peroxidation and the formation of cyclobutane pyrimidine dimers. Afzelin also inhibited UVB-induced cell death in human keratinocytes by inhibiting intrinsic apoptotic signaling. Furthermore, Afzelin showed inhibitory effects on UVB-induced release of pro-inflammatory mediators such as interleukin-6, tumor necrosis factor-α±, and prostaglandin-E2 in human keratinocytes by interfering with the p38 kinase pathway. Using an epidermal equivalent model exposed to UVB radiation, anti-apoptotic activity of Afzelin was also confirmed together with a photoprotective effect at the morphological level[1]

Synonyms	阿福豆苷, Kaempferol-3-O-rhamnoside
Molecular Weight	432.38
Formula	C21H20O10
CAS No.	482-39-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 12 mg/mL (27.75 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage.PLoS One. 2013 Apr 23;8(4):e61971. 1. Shin SW, et al. Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage. PLoS One. 2013 Apr 23;8(4):e61971. 2. Lee SB, et al. Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. Br J Pharmacol. 2017 Jan;174(2):195-209.

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Keywords

Afzelin 482-39-3 G蛋白偶联受体 MAPK信号通路 PI3K/Akt/mTOR信号通路代谢凋亡免疫与炎症微生物学自噬 TNF Mitochondrial Metabolism Autophagy Antibacterial PTEN p38 MAPK Prostaglandin Receptor MMAC1 Phosphatase and tensin homolog inhibit Inhibitor Bacterial Kaempferol-3-O-rhamnoside inhibitor

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