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AlbA-DCA

Catalog No. T13538

AlbA-DCA, a conjugate of Albiziabioside A and a dichloroacetate acid subunit, markedly increases intracellular ROS, alleviates lactic acid accumulation in the tumor microenvironment, selectively kills cancer cells, and induces apoptosis.

AlbA-DCA

AlbA-DCA

Catalog No. T13538
AlbA-DCA, a conjugate of Albiziabioside A and a dichloroacetate acid subunit, markedly increases intracellular ROS, alleviates lactic acid accumulation in the tumor microenvironment, selectively kills cancer cells, and induces apoptosis.
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Product Introduction

Bioactivity
Description
AlbA-DCA, a conjugate of Albiziabioside A and a dichloroacetate acid subunit, markedly increases intracellular ROS, alleviates lactic acid accumulation in the tumor microenvironment, selectively kills cancer cells, and induces apoptosis.
In vitro
AlbA-DCA exhibits cytotoxicity against MCF-7, HCT116, A375, 4T1, HBMEC, and LO2 cells (IC50s: 0.43 μM, 3.87 μM, 3.78 μM, 1.31 μM, 38.20 μM, and 53.14 μM, respectively). Treatment with AlbA-DCA (2 μM; 24 hours) induces apoptosis in MCF-7 cells, significantly up-regulating cytochrome c expression, down-regulating Bcl-2 expression, and enhancing caspase-9 expression.
In vivo
AlbA-DCA (2 mg/kg; subcutaneous injection; every 2 days; for 2 weeks; nude mice) demonstrates significant antitumor efficacy, nearly completely inhibiting tumor progression with no observed mortality or significant changes in body weight. Additionally, AlbA-DCA exhibits no apparent toxicity in the liver and kidney, nor any major abnormalities in the heart, liver, spleen, lung, and kidney.
Chemical Properties
Molecular Weight860.9
FormulaC43H67Cl2NO12
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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