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AnaMorelin hydrochloride

Catalog No. T7225   CAS 861998-00-7
Synonyms: RC-1291 hydrochloride, ONO-7643 hydrochloride

AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).

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AnaMorelin hydrochloride Chemical Structure
AnaMorelin hydrochloride, CAS 861998-00-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 30.00
2 mg In stock $ 43.00
5 mg In stock $ 67.00
10 mg In stock $ 97.00
25 mg In stock $ 148.00
50 mg In stock $ 187.00
100 mg In stock $ 247.00
1 mL * 10 mM (in DMSO) In stock $ 87.00
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Purity: 99.18%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).
Targets&IC50 ghrelin receptor(in the FLIPR assay):0.74 nM(EC50)
In vivo In rats, AnaMorelin hydrochloride(ANAM) significantly and dose-dependently increased FI and BW at all dose levels compared with control, and significantly increased GH levels at 10 or 30 mg/kg doses. Increases in GH and IGF-1 levels were observed following ANAM administration in pigs[1].
Animal Research Fluorescent imaging plate reader and binding assays in HEK293 and baby hamster kidney cells determined the agonist and antagonist activity of ANAM, and its affinity for the ghrelin receptor. Rat pituitary cells were incubated with ANAM to evaluate its effect on growth hormone (GH) release. In vivo, rats were treated with ANAM 3, 10, or 30 mg/kg, or control orally, once daily for 6 days to evaluate the effect on food intake (FI) and body weight (BW), and once to assess GH response. In pigs, single (3.5 mg/kg) or continuous (1 mg/kg/day) ANAM doses were administered to assess GH and insulin-like growth factor (IGF-1) response[1].
Synonyms RC-1291 hydrochloride, ONO-7643 hydrochloride
Molecular Weight 583.16
Formula C31H43ClN6O3
CAS No. 861998-00-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28 mg/mL (48.01 mM)

TargetMolReferences and Literature

1. Pietra C , Takeda Y , Tazawa-Ogata N , et al. Anamorelin HCI (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile[J]. Journal of Cachexia, Sarcopenia and Muscle, 2014, 5(4). 2. Currow D C , Skipworth R J . The emerging role of anamorelin hydrochloride in the management of patients with cancer anorexia-cachexia[J]. Future Oncology, 2017:fon-2017-0141.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Compound Library Bioactive Compounds Library Max GPCR Compound Library Approved Drug Library NO PAINS Compound Library Anti-Lung Cancer Compound Library

Related Products

Related compounds with same targets
TM-N1324 Ibutamoren Mesylate Relamorelin YIL 781 Human growth hormone-releasing factor acetate CJC-1295 acetate(863288-34-0 free base) Obestatin (rat) acetate Anamorelin

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Keywords

AnaMorelin hydrochloride 861998-00-7 GPCR/G Protein GHSR RC 1291 Hydrochloride Inhibitor RC1291 Hydrochloride RC-1291 hydrochloride inhibit ONO7643 Hydrochloride ONO-7643 ONO 7643 RC-1291 Growth hormone secretagogue receptor ONO-7643 hydrochloride ONO7643 ONO 7643 Hydrochloride AnaMorelin Hydrochloride Anamorelin RC-1291 Hydrochloride RC1291 ONO-7643 Hydrochloride RC 1291 inhibitor

 

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