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Arbutamine

Catalog No. T10364 CAS 128470-16-6

Arbutamine is a short-acting synthetic potent nonselective β-adrenoceptor agonist that increases cardiac contractility, heart rate, and systolic blood pressure.

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Arbutamine, CAS 128470-16-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Arbutamine is a short-acting synthetic potent nonselective β-adrenoceptor agonist that increases cardiac contractility, heart rate, and systolic blood pressure.
In vivo	Arbutamine (i.v.; 5, 10, 50, 100, and 250 ng/kg/min) increases mean heart rate, peak positive left ventricular pressure, and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg) [1].

Molecular Weight	317.38
Formula	C18H23NO4
CAS No.	128470-16-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ruiz M, et al. Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses: (99m)Tc-sestamibi versus (201)Tl. J Nucl Med. 2002 May;43(5):664-70. 2. Nagarajan R, et al. A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent. Cardiovasc Drugs Ther. 1996 Mar;10(1):31-8.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Arbutamine 128470-16-6 GPCR/G Protein Neuroscience Adrenergic Receptor Inhibitor inhibitor inhibit

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