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Ayanin

Ayanin
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches.
Catalog No. TN1416Cas No. 572-32-7
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Purity:98.9%
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Ayanin

Purity: 98.9%
Catalog No. TN1416Cas No. 572-32-7

Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$176In Stock
5 mg$373In Stock
10 mg$527In Stock
25 mg$768In Stock
50 mg$1,050In Stock
100 mg$1,420In Stock
200 mg$1,890In Stock
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Product Introduction

Bioactivity
Description
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) is 2.2microM for inhibiting interleukin (IL)-4 production from purified basophils.
Targets&IC50
IL-4:2.2 μM
In vitro
Incubation of human leukemia cells with Ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with Ayanin diacetate and TRAIL amplified cell death, compared to single treatments.
Chemical Properties
Molecular Weight344.32
FormulaC18H16O7
Cas No.572-32-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 245 mg/mL (711.55 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9043 mL14.5214 mL29.0428 mL145.2138 mL
5 mM0.5809 mL2.9043 mL5.8086 mL29.0428 mL
10 mM0.2904 mL1.4521 mL2.9043 mL14.5214 mL
20 mM0.1452 mL0.7261 mL1.4521 mL7.2607 mL
50 mM0.0581 mL0.2904 mL0.5809 mL2.9043 mL
100 mM0.0290 mL0.1452 mL0.2904 mL1.4521 mL

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