Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 622.00 | |
10 mg | In stock | $ 879.00 | |
25 mg | In stock | $ 1,280.00 | |
50 mg | In stock | $ 1,750.00 | |
100 mg | In stock | $ 2,370.00 |
Description | Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches. |
Targets&IC50 | IL-4:2.2 μM |
In vitro | Incubation of human leukemia cells with Ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with Ayanin diacetate and TRAIL amplified cell death, compared to single treatments. |
Source |
Molecular Weight | 344.32 |
Formula | C18H16O7 |
CAS No. | 572-32-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 245 mg/mL (711.55 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ayanin 572-32-7 Chromatin/Epigenetic DNA Damage/DNA Repair Immunology/Inflammation Metabolism IL Receptor P450 PARP PDE hypertension airway hyperresponsiveness Phosphodiesterase (PDE) Inhibitor inhibit respiratory disease allergic asthma tracheal relaxant inhibitor