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BIBO3304 TFA

Name: BIBO3304 TFA
Brand: TargetMol
SKU: T10539
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).

Catalog No. T10539Cas No. 191868-14-1

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Purity:99.50%

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COA HPLC HNMR LCMS

BIBO3304 TFA

Catalog No. T10539Cas No. 191868-14-1

BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$98	In Stock
2 mg	$148	In Stock
5 mg	$233	In Stock
10 mg	$412	In Stock
25 mg	$686	In Stock
50 mg	$977	In Stock
100 mg	$1,320	In Stock
1 mL x 10 mM (in DMSO)	$348	In Stock

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Product Introduction

Bioactivity

Description	BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).
Targets&IC50	NPYY1 receptor:0.38 nM(human), NPYY1 receptor:0.72 nM (rat)
In vivo	BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding response mediated by 1 μg NPY. BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting [1]. BIBO3304 TFA (0.5?μM; p.o.) significantly increases serum insulin levels [2].

Chemical Properties

Molecular Weight	643.66
Formula	C₃₁H₃₆F₃N₇O₅
Cas No.	191868-14-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (155.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5536 mL	7.7681 mL	15.5362 mL	77.6808 mL
5 mM	0.3107 mL	1.5536 mL	3.1072 mL	15.5362 mL
10 mM	0.1554 mL	0.7768 mL	1.5536 mL	7.7681 mL
20 mM	0.0777 mL	0.3884 mL	0.7768 mL	3.8840 mL
50 mM	0.0311 mL	0.1554 mL	0.3107 mL	1.5536 mL
100 mM	0.0155 mL	0.0777 mL	0.1554 mL	0.7768 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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