Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 188.00 | |
10 mg | In stock | $ 315.00 | |
25 mg | In stock | $ 529.00 | |
50 mg | In stock | $ 768.00 | |
100 mg | In stock | $ 1,080.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 260.00 |
Description | BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes. |
In vitro | BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. It presents low toxicity towards tested cell lines and blocks the interaction of soluble PD-L1 with the cell surface-expressed PD-1. |
Molecular Weight | 631.11 |
Formula | C35H35ClN2O7 |
CAS No. | 2113650-04-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11.5 mg/mL(18.22 mM)
You can also refer to dose conversion for different animals. More
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BMS-1001 hydrochloride 2113650-04-5 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 Inhibitor BMS 1001 BMS-1001 Hydrochloride inhibit ICB toxicity BMS1001 immune checkpoint BMS1001 Hydrochloride BMS 1001 hydrochloride BMS 1001 Hydrochloride BMS-1001 BMS1001 hydrochloride low inhibitor