Shopping Cart
- Remove All
- Your shopping cart is currently empty
BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $56 | In Stock | |
5 mg | $133 | In Stock | |
10 mg | $197 | In Stock | |
25 mg | $333 | In Stock | |
50 mg | $470 | In Stock | |
100 mg | $653 | In Stock | |
200 mg | $879 | In Stock |
Description | BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay). |
In vitro | The small-molecule inhibitors of the PD-1/PD-L1 interaction, BMS-1001 , ?bind to human PD-L1 and block its interaction with PD-1, when tested on isolated proteins.?The compounds present low toxicity towards tested cell lines and block the interaction of soluble PD-L1 with the cell surface-expressed PD-1.?BMS-1001 alleviate the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.?Moreover, the compounds were effective in attenuating the inhibitory effect of the cell surface-associated PD-L1. |
Molecular Weight | 594.7 |
Formula | C35H34N2O7 |
Cas No. | 2113650-03-4 |
Smiles | CC1=CC(CN[C@H](CO)C(O)=O)=C(OCC2=CC(=CC=C2)C#N)C=C1OCC1=C(C)C(=CC=C1)C1=CC2=C(OCCO2)C=C1 |
Relative Density. | 1.34 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 5.94 mg/mL (10 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.