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BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 48 € | In Stock | |
5 mg | 122 € | In Stock | |
10 mg | 197 € | In Stock | |
25 mg | 401 € | In Stock | |
50 mg | 645 € | In Stock | |
100 mg | 1.026 € | In Stock | |
200 mg | 1.377 € | In Stock | |
1 mL x 10 mM (in DMSO) | 172 € | In Stock |
Description | BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes. |
In vitro | BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. It presents low toxicity towards tested cell lines and blocks the interaction of soluble PD-L1 with the cell surface-expressed PD-1. |
Molecular Weight | 631.11 |
Formula | C35H35ClN2O7 |
Cas No. | 2113650-04-5 |
Smiles | Cl.Cc1cc(CN[C@H](CO)C(O)=O)c(OCc2cccc(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 11.5 mg/mL (18.22 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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