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BMS453
BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.
Catalog No. T21714Cas No. 166977-43-1
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Purity:99.78%
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BMS453
Catalog No. T21714Cas No. 166977-43-1
BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $58 | In Stock | |
| 10 mg | $97 | In Stock | |
| 25 mg | $217 | In Stock | |
| 50 mg | $325 | In Stock | |
| 100 mg | $469 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $91 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ. |
| In vitro | BMS453 (1 μM; 11 hours; 184 and HMEC cells) inhibits normal breast cell proliferation without significantly inducing apoptosis[2]. The RARβ-selective agonist (BMS453) significantly reduces T47D breast cancer cell migration to levels comparable to RA inhibition, unlike RARα- or RARγ-selective agonists (BMS753 and BMS961), indicating RARβ's role in RA-inhibited cell migration[3]. |
| Alias | BMS 453, BMS-189453 |
| Molecular Weight | 380.48 |
| Formula | C27H24O2 |
| Cas No. | 166977-43-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (118.27 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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