Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPR1J-097, a new-type small molecule FLT-3 inhibitor(IC50=11±7 nM), is with great anti-tumor activities in vivo.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 43.00 | |
2 mg | In stock | $ 60.00 | |
5 mg | In stock | $ 96.00 | |
10 mg | In stock | $ 157.00 | |
25 mg | In stock | $ 285.00 | |
50 mg | In stock | $ 482.00 | |
100 mg | In stock | $ 689.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 151.00 |
Description | BPR1J-097, a new-type small molecule FLT-3 inhibitor(IC50=11±7 nM), is with great anti-tumor activities in vivo. |
Targets&IC50 | FLT3 (D835Y):3 nM, FLT3:11±7 Nm, MOLM-13 and MV4-11 cells:21±7 and 46±14 nM |
In vivo | In FLT3-driven AML murine xenograft models, BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells and pronounced dose-dependent tumour growth inhibition and regression. |
Kinase Assay | Cells are treated with THZ531 for 6 hours.After treatment cells are washed 2-fold with cold PBS and then lysed in the following lysis buffer: Hepes(50 mM, pH 7.4), NaCl(150 mM), 1% Nonidet P40 substitute, EDTA(5 mM), DTT(1 mM), and protease/phosphatase cocktails.Lysates are treated with bio-THZ1 or bio-TH531 for pulldown overnight at 4°C. |
Molecular Weight | 553.07 |
Formula | C27H29ClN6O3S |
CAS No. | T4261 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.53 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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BPR1J-097 hydrochloride (1327167-19-0(free base)) T4261 Angiogenesis Tyrosine Kinase/Adaptors FLT BPR1J 097 hydrochloride (1327167 19 0(free base)) BPR-1J-097 hydrochloride (1327167-19-0(free base)) BPR1J097 hydrochloride (1327167190(free base)) inhibitor inhibit