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BTYNB

Catalog No. T9033 CAS 304456-62-0

Synonyms: MDK6620, BTYNB IMP1 Inhibitor

BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). It disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association

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BTYNB, CAS 304456-62-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 40.00
10 mg	In stock	$ 57.00
25 mg	In stock	$ 94.00
50 mg	In stock	$ 138.00
100 mg	In stock	$ 209.00
200 mg	In stock	$ 325.00
500 mg	In stock	$ 593.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.91%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). It disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association
Targets&IC50	IMP1 c-Myc mRNA internation:5 μM (IC50)
In vitro	In cells, BTYNB downregulates several mRNA transcripts regulated by IMP1.?BTYNB destabilizes c-Myc mRNA, resulting in downregulation of c-Myc mRNA and protein.?BTYNB downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB).?The oncogenic translation regulator, eEF2, emerged as a new IMP1 target mRNA, enabling BTYNB to inhibit tumor cell protein synthesis.?BTYNB potently inhibited proliferation of IMP1-containing ovarian cancer and melanoma cells with no effect in IMP1-negative cells.?Overexpression of IMP1 reversed BTYNB inhibition of cell proliferation.?BTYNB completely blocked anchorage-independent growth of melanoma and ovarian cancer cells in colony formation assays.?With its ability to target c-Myc and to inhibit proliferation of difficult-to-target melanomas and ovarian cancer cells, and with its unique mode of action, BTYNB is a promising small molecule for further therapeutic evaluation and mechanistic studies[1].

Synonyms	MDK6620, BTYNB IMP1 Inhibitor
Molecular Weight	309.18
Formula	C12H9BrN2OS
CAS No.	304456-62-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62 mg/mL (200.53 mM)

Ethanol: 4 mg/mL (12.94 mM)

References and Literature

1. Mahapatra L , Andruska N , Mao C , et al. A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation[J]. Translational Oncology, 2017, 10(5):818-827. 2. Simon M , Nadine B , Bianca B , et al. The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer[J]. Nucleic Acids Research, 2020(15):15.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Reprogramming Compound Library Wnt/Hedgehog/Notch Compound Library Anti-Cancer Metabolism Compound Library Anti-Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Lung Cancer Compound Library Cell Cycle Compound Library Antidepressant Compound Library Glycolysis Compound Library

Related Products

Related compounds with same targets

MDEG-541 10074-G5 MYCi361 c-Myc inhibitor 12 Mycro 3 10058-F4 Aaptamine ML327

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Keywords

BTYNB 304456-62-0 Cell Cycle/Checkpoint NF-Κb Others c-Myc NF-κB Inhibitor inhibit ES-2 IMP1 Myc MDK-6620 IGROV-1 MDK6620 MDK 6620 BTYNB IMP1 Inhibitor cancer cell SK-MEL2 inhibitor

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