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Balicatib

Catalog No. T1850 CAS 354813-19-7

Synonyms: AAE581

Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.

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Balicatib, CAS 354813-19-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 35.00
5 mg	In stock	$ 56.00
10 mg	In stock	$ 101.00
25 mg	In stock	$ 235.00
50 mg	In stock	$ 441.00
100 mg	In stock	$ 636.00
500 mg	In stock	$ 1,330.00
1 mL * 10 mM (in DMSO)	In stock	$ 62.00

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Purity: 98.09%

Purity: 98%

Purity: 97.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.
Kinase Assay	Cell-free kinase activity assays: Glutathione-S-transferase (GST)-tagged JAK kinase domains expressed in insect cells are purified before use in a peptide substrate phosphorylation assay. Assays are carried out in 384-well optiplates using an Alphascreen Protein Tyrosine Kinase P100 detection kit and a PerkinElmer Fusion Alpha instrument.

Synonyms	AAE581
Molecular Weight	411.54
Formula	C23H33N5O2
CAS No.	354813-19-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (121.49 mM)

References and Literature

1. Jerome C, et al. Osteoporos Int. 2012 Jan;23(1):339-49.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Anti-Metabolism Disease Compound Library Protease Inhibitor Library Bioactive Compound Library Target-Focused Phenotypic Screening Library Endocrinology-Hormone Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

Cathepsin Inhibitor 1 PD 151746 Tacalcitol monohydrate Z-Lys-OH PMSF E-64 LHVS Aloxistatin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Balicatib 354813-19-7 Proteases/Proteasome Cysteine Protease AAE581 AAE 581 osteoporosis inhibit AAE-581 Inhibitor bone formation dermal fibroblasts Cathepsin bone turnover inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.