Shopping Cart
- Remove All
![TargetMol](https://newstatic.targetmol.com/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $38 | In Stock | |
2 mg | $54 | In Stock | |
5 mg | $85 | In Stock | |
10 mg | $142 | In Stock | |
25 mg | $269 | In Stock | |
50 mg | $482 | In Stock | |
100 mg | $689 | In Stock | |
500 mg | $1,480 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM). |
In vivo | The pretreatment of Anavex 2-73 (1/3 mg/kg) dose-dependently reduces the scopolamine-induced alternation deficit. The pretreatment with Anavex 2-73 (>0.3 mg/kg) dose-dependently and significantly attenuates the impairments of step-through latency[1]. The Anavex 2-73 (1?mg/kg) dose-dependently blocks the recognition memory deficit. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Anavex 2-73 (0.1/1?mg/kg). Seven days after injections, Anavex 2-73 attenuates the decrease in Ser9 phosphorylation induced by the peptide (0.3/1?mg/kg)[2]. |
Animal Research | Drugs (including Anavex 2-73) are solubilized in physiological saline at the concentration of 5?mg/mL.Male mice aged 7-9 weeks and weighing 32±2?g are used. Drugs (including Anavex 2-73) are brought up to each dose by dilution and injected in a volume of 100?μL/20?g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures. |
Alias | Anavex 2-73, AVex-73 hydrochloride, AE-37 hydrochloride |
Molecular Weight | 317.85 |
Formula | C19H24ClNO |
Cas No. | 195615-84-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (173.04 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.