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Blonanserin
Catalog No. T1180Cas No. 132810-10-7
Alias AD-5423
Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal symptoms, excessive sedation, or hypotension.
Blonanserin
Catalog No. T1180Alias AD-5423Cas No. 132810-10-7
Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal symptoms, excessive sedation, or hypotension.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $31 | In Stock | |
| 10 mg | $48 | In Stock | |
| 25 mg | $85 | In Stock | |
| 50 mg | $126 | In Stock | |
| 100 mg | $175 | In Stock | |
| 200 mg | $315 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal symptoms, excessive sedation, or hypotension. |
| Targets&IC50 | 5-HT2:3.98 nM(Ki), D2 receptor:14.8 nM(Ki) |
| In vitro | In tests of atypical antipsychotics (risperidone, olanzapine, and aripiprazole), Blonanserin showed the most potent binding affinity for human D3 receptors.Blonanserin transiently increased neuronal firing in the nucleus of the pallidum and ventral tegmental area, but not in the nucleus medius dorsalis or the medial dorsal nucleus of the thalamus, whereas risperidone increased firing in the nucleus ventral tegmental area and in the nucleus medius dorsalis but not in the nucleus dorsalis. in the medial dorsal nucleus of the rat thalamus. Blonanserin consistently increased additional extracellular levels of norepinephrine and dopamine but not serotonin, GABA, or glutamate, whereas risperidone consistently increased levels of norepinephrine, dopamine, and serotonin but not GABA or glutamate.Blonanserin increased the efflux of cortical DA and its metabolites, homovanillic acid and 3,4-dihydroxy Phenylacetic acid. |
| In vivo | In tests of atypical antipsychotics (risperidone, olanzapine, and aripiprazole), Blonanserin showed the most potent binding affinity for human D3 receptors.Blonanserin transiently increased neuronal firing in the nucleus of the pallidum and ventral tegmental area, but not in the nucleus medius dorsalis or the medial dorsal nucleus of the thalamus, whereas risperidone increased firing in the nucleus ventral tegmental area and in the nucleus medius dorsalis but not in the nucleus dorsalis. in the medial dorsal nucleus of the rat thalamus. Blonanserin consistently increased additional extracellular levels of norepinephrine and dopamine but not serotonin, GABA, or glutamate, whereas risperidone consistently increased levels of norepinephrine, dopamine, and serotonin but not GABA or glutamate.Blonanserin increased the efflux of cortical DA and its metabolites, homovanillic acid and 3,4-dihydroxy Phenylacetic acid. |
| Alias | AD-5423 |
| Molecular Weight | 367.5 |
| Formula | C23H30FN3 |
| Cas No. | 132810-10-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 14.29 mg/mL (38.88 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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