keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 80.00 | |
25 mg | In stock | $ 133.00 | |
50 mg | In stock | $ 197.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway. |
Targets&IC50 | Na+, K+-ATPase α1:42.5 nM (Kd), Na+, K+-ATPase α2:45 nM (Kd), Na+, K+-ATPase α3:40 nM (Kd) |
Molecular Weight | 386.52 |
Formula | C24H34O4 |
CAS No. | 465-21-4 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (129.36 mM)
You can also refer to dose conversion for different animals. More
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Bufalin 465-21-4 Membrane transporter/Ion channel ATPase Inhibitor Sodium potassium pump Na+/K+ ATPase inhibit inhibitor