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CM-579

Catalog No. T10840L   CAS 1846570-40-8

CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CM-579 Chemical Structure
CM-579, CAS 1846570-40-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 50.00
5 mg In stock $ 97.00
10 mg In stock $ 141.00
25 mg In stock $ 229.00
50 mg In stock $ 336.00
100 mg In stock $ 496.00
1 mL * 10 mM (in DMSO) In stock $ 126.00
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Purity: 99.62%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
Targets&IC50 DNMT3B:1000 nM, G9a:16 nM, DNMT3a:92 nM, DNA methyltransferase:32 nM, DNMT1:1.5 nM (kd)
In vitro CM-579 inhibits DNMT3A and DNMT3B ( IC50s: 92 nM and 1000 nM). The Kd of CM-579 for DNMT1 is 1.5 nM. [1]
Molecular Weight 492.65
Formula C29H40N4O3
CAS No. 1846570-40-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (91.34 mM)

TargetMolReferences and Literature

1. San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Epigenetics Compound Library Anti-Cancer Compound Library Bioactive Compound Library Inhibitor Library Histone Modification Compound Library Bioactive Compounds Library Max

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Keywords

CM-579 1846570-40-8 Chromatin/Epigenetic DNA Methyltransferase Histone Methyltransferase CM 579 CM579 inhibitor inhibit

 

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