Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 141.00 | |
25 mg | In stock | $ 229.00 | |
50 mg | In stock | $ 336.00 | |
100 mg | In stock | $ 496.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 126.00 |
Description | CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells. |
Targets&IC50 | DNMT3B:1000 nM, G9a:16 nM, DNMT3a:92 nM, DNA methyltransferase:32 nM, DNMT1:1.5 nM (kd) |
In vitro | CM-579 inhibits DNMT3A and DNMT3B ( IC50s: 92 nM and 1000 nM). The Kd of CM-579 for DNMT1 is 1.5 nM. [1] |
Molecular Weight | 492.65 |
Formula | C29H40N4O3 |
CAS No. | 1846570-40-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (91.34 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CM-579 1846570-40-8 Chromatin/Epigenetic DNA Methyltransferase Histone Methyltransferase CM 579 CM579 inhibitor inhibit