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CM-579 trihydrochloride (1846570-40-8 free base)

Catalog No. T10840
Alias CM-579 trihydrochloride

CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide range of cancer cells.

CM-579 trihydrochloride (1846570-40-8 free base)

CM-579 trihydrochloride (1846570-40-8 free base)

Catalog No. T10840Alias CM-579 trihydrochloride
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide range of cancer cells.
Pack SizePriceAvailabilityQuantity
5 mg$223Backorder
10 mg$346Backorder
50 mg$971Backorder
100 mg$1,323Backorder
200 mgInquiryBackorder
500 mgInquiryBackorder
1 mL x 10 mM (in DMSO)$295Backorder
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Product Introduction

Bioactivity
Description
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide range of cancer cells.
Targets&IC50
G9a:16 nM, DNMT3B:1000 nM, DNA methyltransferase:32 nM, DNMT3A:92 nM, DNMT1:1.5 nM (kd)
AliasCM-579 trihydrochloride
Chemical Properties
Molecular Weight602.04
FormulaC29H43Cl3N4O3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 37.5 mg/mL (62.29 mM), Sonication is recommended.
DMSO: 125 mg/mL (207.63 mM), Sonication is recommended.
MEthanol: 75 mg/mL (124.58 mM), Sonication is recommended.
Solution Preparation Table
H2O/MEthanol/DMSO
1mg5mg10mg50mg
1 mM1.6610 mL8.3051 mL16.6102 mL83.0510 mL
5 mM0.3322 mL1.6610 mL3.3220 mL16.6102 mL
10 mM0.1661 mL0.8305 mL1.6610 mL8.3051 mL
20 mM0.0831 mL0.4153 mL0.8305 mL4.1525 mL
50 mM0.0332 mL0.1661 mL0.3322 mL1.6610 mL
MEthanol/DMSO
1mg5mg10mg50mg
100 mM0.0166 mL0.0831 mL0.1661 mL0.8305 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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