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CM-579

🥰Excellent
Catalog No. T10840LCas No. 1846570-40-8

CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.

CM-579

CM-579

🥰Excellent
Purity: 99.62%
Catalog No. T10840LCas No. 1846570-40-8
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
Pack SizePriceAvailabilityQuantity
1 mg$50In Stock
5 mg$97In Stock
10 mg$141In Stock
25 mg$229In Stock
50 mg$336In Stock
100 mg$496In Stock
1 mL x 10 mM (in DMSO)$126In Stock
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Purity:99.62%
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Product Introduction

Bioactivity
Description
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
Targets&IC50
DNMT3A:92 nM, DNMT1:1.5 nM (kd), G9a:16 nM, DNMT3B:1000 nM, DNA methyltransferase:32 nM
In vitro
CM-579 inhibits DNMT3A and DNMT3B ( IC50s: 92 nM and 1000 nM). The Kd of CM-579 for DNMT1 is 1.5 nM. [1]
Chemical Properties
Molecular Weight492.65
FormulaC29H40N4O3
Cas No.1846570-40-8
SmilesN(CC1CCN(C)CC1)C=2C3=C(N=C(C2)C=4OC(C)=CC4)C=C(OCCCN5CCCC5)C(OC)=C3
Relative Density.1.143 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (91.34 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0298 mL10.1492 mL20.2984 mL101.4919 mL
5 mM0.4060 mL2.0298 mL4.0597 mL20.2984 mL
10 mM0.2030 mL1.0149 mL2.0298 mL10.1492 mL
20 mM0.1015 mL0.5075 mL1.0149 mL5.0746 mL
50 mM0.0406 mL0.2030 mL0.4060 mL2.0298 mL

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