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CPI-637

Catalog No. T6811   CAS 1884712-47-3
Synonyms: CPI 637

CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CPI-637 Chemical Structure
CPI-637, CAS 1884712-47-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 47.00
5 mg In stock $ 71.00
10 mg In stock $ 102.00
25 mg In stock $ 223.00
50 mg In stock $ 397.00
100 mg In stock $ 597.00
500 mg In stock $ 1,260.00
1 mL * 10 mM (in DMSO) In stock $ 71.00
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Purity: 99.91%
Purity: 99.75%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
Targets&IC50 CBP:0.03 μM, EP300:0.051 μM
In vitro CPI-637 inhibits MYC expression in AMO-1 cells (EC50=0.60 μM)[1].
Kinase Assay Ki Determination: Inhibition of human full-length recombinant PARP-1 by [32P]NAD+ incorporation is measured. The [32P]ADP-ribose incorporated into acid insoluble material is quantified using a PhosphorImager. Ki is calculated by nonlinear regression analysis.
Cell Research AMO-1 cells (DSMZ) were plated at 20,000 cells/well in 96-well plates in Iscove's Modified Dulbecco's Medium supplemented with 10% fetal calf serum. Cells were treated for 6 h with a dose titration of CPI-637 starting from a 5 μM top concentration. After 6 h, cells were lysed and processed for QuantiGene Plex expression analysis and data were collected on a MAGPIX multiplex Luminex instrument.(Only for Reference)
Synonyms CPI 637
Molecular Weight 386.45
Formula C22H22N6O
CAS No. 1884712-47-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 26 mg/mL (67.3 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Taylor AM, et al. ACS Med Chem Lett. 2016, 7(5):531-6. 2. Lang J Y, Wang X, Xie Q, et al. Targeting KRAS-mutant stomach/colorectal tumours by disrupting the ERK2-p53 complex[J]. bioRxiv. 2020

TargetMolCitations

1. Wang X, Xie Q, Ji Y, et al.Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex.Cell Reports.2023, 42(1): 111972.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Histone Modification Compound Library PPI Inhibitor Library NO PAINS Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max Kinase Inhibitor Library Reprogramming Compound Library Epigenetics Compound Library Bioactive Compound Library

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CBP/p300-IN-3 Procyanidin B3 PF-9363 JG-2016 Acetaminophen Crebinostat MOZ-IN-2 Curcumin

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Keywords

CPI-637 1884712-47-3 Chromatin/Epigenetic Histone Acetyltransferase Epigenetic Reader Domain Inhibitor inhibit HAT HATs CPI637 CPI 637 inhibitor

 

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