Shopping Cart

Remove All

Your shopping cart is currently empty

CX-6258 hydrochloride

Select Batch

Purity:98.00%

Resource Download

COA HNMR

CX-6258 hydrochloride

Catalog No. T6148Cas No. 1353859-00-3

CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$36	In Stock
2 mg	$51	In Stock
5 mg	$80	In Stock
10 mg	$147	In Stock
25 mg	$267	In Stock
50 mg	$447	In Stock
100 mg	$643	In Stock
500 mg	$1,330	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "CX-6258 hydrochloride"

Product Introduction

Bioactivity

Description	CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).
In vitro	CX-6258 has anti-proliferative activity against a panel of human cancer cell lines (IC50: 0.02-3.7 μM), mostly sensitive to acute leukemia cell lines. Combinations of CX-6258 with doxorubicin (10:1 molar ratio) and CX-6258 with paclitaxel (100:1 molar ratio) produces synergistic cell killing (CI50: 0.4 and 0.56).
In vivo	In mice carrying MV-4-11 xenografts, CX-6258 dose-dependently suppresses the tumor growth , with a 50/100 mg/kg dose producing 45%/75% tumor growth inhibition.
Kinase Assay	Pim-1 and Pim-2 inhibitions are measured in radiometric assays using human recombinant Pim-1 at [ATP] = 30 μM (substrate RSRHSSYPAGT) and human recombinant Pim-2 at [ATP] = 5 μM (substrate RSRHSSYPAGT). The radiometric assay for Pim-3 uses RSRHSSYPAGT as a substrate in the presence of [ATP] = 155 μM.
Alias	CX-6258 HCl, Pim-Kinase Inhibitor X

Chemical Properties

Molecular Weight	498.4
Formula	C26H24ClN3O3·HCl
Cas No.	1353859-00-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 82 mg/mL (164.5 mM)

DMSO: 53 mg/mL (106.3 mM)

Ethanol: 1 mg/mL (2.0 mM)

Solution Preparation Table

H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.0064 mL	10.0321 mL	20.0642 mL	100.3210 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.4013 mL	2.0064 mL	4.0128 mL	20.0642 mL
10 mM	0.2006 mL	1.0032 mL	2.0064 mL	10.0321 mL
20 mM	0.1003 mL	0.5016 mL	1.0032 mL	5.0161 mL
50 mM	0.0401 mL	0.2006 mL	0.4013 mL	2.0064 mL
100 mM	0.0201 mL	0.1003 mL	0.2006 mL	1.0032 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc