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Chetomin

Catalog No. T6804 CAS 1403-36-7

Synonyms: Chaetomin, NSC289491, BRN0077366

Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.

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Chetomin, CAS 1403-36-7

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 98.00
2 mg	Inquiry	$ 175.00
5 mg	Inquiry	$ 316.00
10 mg	Inquiry	$ 506.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
In vitro	HIF-1 (hypoxia-inducible factors 1) is transcription factor which respond to changes of cellular environment oxygen[2]. Chetomin selectively inhibits HIF-1 activities through disruption of the interaction of HIF-1 with its transcriptional coactivator p300. HIF-1 inhibition by chetomin effectively reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro[1]. Chetomin attenuates the hypoxia-induced radioresistance of malignant glioma cell lines U251 mg (DMF10: 1.35 and 1.18) and U343 mg (DMF10: 1.78 and 1.48)[3]. Targeting of HIF-1 using chetomin abolishes the differentiation-inhibitory effect of hypoxia-inducible factor-1α[4].
In vivo	Administration of chetomin in combination with forskolin significantly suppresses malignant glioma growth in an in vivo xenograft model [4]. Che-M(chetomin loaded micelles) dramatically inhibits embryonic angiogenesis, tumor-induced angiogenesis and tumor growth in zebrafish. In mouse model, Che-M suppresses tumor growth and prolongs the survival in the subcutaneous CT26 tumor model [5].
Cell Research	In RT-PCR and clonogenic survival experiments, chetomin is added in a concentration of 150 nM to fully supplemented medium four hours before treatment with hypoxia. HT 1080 cells are then transferred to the hypoxic workstation (0.1% O2, 12 h) or to the well-humidified incubator (12 hours) without changing medium. HT1080 cells are thus treated for 16 hours with chetomin (150 nM) prior to radiation treatment. (Only for Reference)

Synonyms	Chaetomin, NSC289491, BRN0077366
Molecular Weight	710.87
Formula	C31H30N6O6S4
CAS No.	1403-36-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Ethanol: 10 mg/mL (14.06 mM)

H2O: <1 mg/mL

DMSO: 93 mg/mL (130.8 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Staab A,et al. BMC Cancer. 2007, 7:231. 2. Thomas G Smith, et al. Br J Haematol. 2008, 141(3):325–334. 3. Thomas G Smith, et al. BMC Cancer. 2010, 10:605. 4. Lu H, et al. FEBS J. 2009, 276(24):7291-7304. 5. Wu Q, et al. Nanoscale. 2014, 6(20):11940-11952.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Chetomin 1403-36-7 Angiogenesis Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling Metabolism HIF HSP Heat shock proteins targeting nontoxic Chaetomium NSCLC hypoxia-inducible potent non-small Chaetomin NSC289491 inhibit globosum Inhibitor BRN0077366 inhibitor

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