Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 98.00 | |
2 mg | Inquiry | $ 175.00 | |
5 mg | Inquiry | $ 316.00 | |
10 mg | Inquiry | $ 506.00 |
Description | Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations. |
In vitro | HIF-1 (hypoxia-inducible factors 1) is transcription factor which respond to changes of cellular environment oxygen[2]. Chetomin selectively inhibits HIF-1 activities through disruption of the interaction of HIF-1 with its transcriptional coactivator p300. HIF-1 inhibition by chetomin effectively reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro[1]. Chetomin attenuates the hypoxia-induced radioresistance of malignant glioma cell lines U251 mg (DMF10: 1.35 and 1.18) and U343 mg (DMF10: 1.78 and 1.48)[3]. Targeting of HIF-1 using chetomin abolishes the differentiation-inhibitory effect of hypoxia-inducible factor-1α[4]. |
In vivo | Administration of chetomin in combination with forskolin significantly suppresses malignant glioma growth in an in vivo xenograft model [4]. Che-M(chetomin loaded micelles) dramatically inhibits embryonic angiogenesis, tumor-induced angiogenesis and tumor growth in zebrafish. In mouse model, Che-M suppresses tumor growth and prolongs the survival in the subcutaneous CT26 tumor model [5]. |
Cell Research | In RT-PCR and clonogenic survival experiments, chetomin is added in a concentration of 150 nM to fully supplemented medium four hours before treatment with hypoxia. HT 1080 cells are then transferred to the hypoxic workstation (0.1% O2, 12 h) or to the well-humidified incubator (12 hours) without changing medium. HT1080 cells are thus treated for 16 hours with chetomin (150 nM) prior to radiation treatment. (Only for Reference) |
Synonyms | Chaetomin, NSC289491, BRN0077366 |
Molecular Weight | 710.87 |
Formula | C31H30N6O6S4 |
CAS No. | 1403-36-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Ethanol: 10 mg/mL (14.06 mM)
H2O: <1 mg/mL
DMSO: 93 mg/mL (130.8 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Chetomin 1403-36-7 Angiogenesis Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling Metabolism HIF HSP Heat shock proteins targeting nontoxic Chaetomium NSCLC hypoxia-inducible potent non-small Chaetomin NSC289491 inhibit globosum Inhibitor BRN0077366 inhibitor