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Cimiracemoside C

Catalog No. TN1499 CAS 256925-92-5

Synonyms: Cimicifugoside M

Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.

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Cimiracemoside C, CAS 256925-92-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 68.00
5 mg	In stock	$ 165.00
10 mg	In stock	$ 283.00
25 mg	In stock	$ 478.00
50 mg	In stock	$ 687.00
100 mg	In stock	$ 957.00
1 mL * 10 mM (in DMSO)	In stock	$ 243.00

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Purity: 99.73%

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Description	Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.
In vitro	Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and Cimiracemoside C) were investigated in vitro for their effects on AMP-activated protein kinase (AMPK) compared to metformin in HepaRG cells. Ze 450 (given orally (PO) and intraperitonally (IP)), metformin (PO) and controls were given over 7 days to 68 male ob/ob mice. Glucose and insulin concentrations were measured at baseline and during an oral glucose tolerance test (OGTT). Ze 450 and its components activated AMPK to the same extent as metformin. In mice, Ze 450 (PO/IP) decreased significantly average daily and cumulative weight gain, average daily food and water intake, while metformin had no effect. In contrast to metformin, PO Ze 450 virtually did not change maximum glucose levels during OGTT, however, prolonged elimination. Ze 450 administered PO and IP decreased significantly post-stimulated insulin, whereas metformin did not. HOMA-IR index of insulin resistance improved significantly after IP and PO Ze 450 and slightly after metformin. In summary, the results demonstrate that Ze 450 reduced significantly body weight, plasma glucose, improved glucose metabolism and insulin sensitivity in diabetic ob/ob mice. In vitro experiments suggest that part of the effects may be related to AMPK activation.
Source	Natural Products > Ranunculaceae > Cimicifuga

Synonyms	Cimicifugoside M
Molecular Weight	620.81
Formula	C35H56O9
CAS No.	256925-92-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.21 mg/mL (10 mM)

References and Literature

1. Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice.Phytomedicine. 2014 Sep 25;21(11):1382-9.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Kinase Inhibitor Library Bioactive Compounds Library Max PI3K-AKT-mTOR Compound Library Reprogramming Compound Library Anti-Lung Cancer Compound Library Anti-Hypertension Compound Library Anti-Tumor Natural Product Library Anti-Breast Cancer Compound Library Epigenetics Compound Library

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Keywords

Cimiracemoside C 256925-92-5 Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK AMP-activated protein kinase inhibit Inhibitor Cimicifugoside M inhibitor

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