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Cirsilineol

Catalog No. T19886 CAS 41365-32-6

Synonyms: Fastigenin, SPM 927, Eupatrin

Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathway.

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Cirsilineol, CAS 41365-32-6

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Description	Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathway.
In vitro	Cirsilineol (0.1, 1, 10 μM) dose-dependently inhibits single mixed lymphocyte reaction and the proliferation of Concanava A-induced T-cells in Splenocytes. Cirsilineol (1, 5, 10 μM) inhibits IFN-γ-induced Tyr701 phosphorylation of STAT1 and the activation of JAK2 in Splenic CD4+ T cells[3].
In vivo	In female C57BL/6, BALB/c, and DO11.10 transgenic mice with TNBS, Cirsilineol (3-30 mg/kg) reduces inflammatory infiltration, restores the destructive mucosal architecture, and remisses edema thus improving the effects on the body weights and survival rate of mice. Cirsilineol ameliorates TNBS-induced Th1-mediated colitis by inhibiting IFN-γ/STAT1/T-bet signaling in CD4+ T cells[1].

Synonyms	Fastigenin, SPM 927, Eupatrin
Molecular Weight	344.32
Formula	C18H16O7
CAS No.	41365-32-6

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Polatoğlu K, et al. Chemistry and biological activities of Tanacetum chiliophyllum var. oligocephalum extracts. J AOAC Int. 2013 Nov-Dec;96(6):1222-7. 2. Sheng X, et al. Cirsilineol inhibits proliferation of cancer cells by inducing apoptosis via mitochondrial pathway. J Pharm Pharmacol. 2008 Nov;60(11):1523-9. 3. Yang Sun, et al. Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease. Biochem Pharmacol. 2010 Jan 15;79(2):229-38. 4. Hammoud L, et al. A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M. Nat Prod Res. 2012;26(3):203-8.

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Keywords

Cirsilineol 41365-32-6 Apoptosis Immunology/Inflammation JAK/STAT signaling Neuroscience Stem Cells STAT COX SPM-927 Fastigenin SPM 927 Eupatrin SPM927 inhibitor inhibit

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