keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 76.00 | |
5 mg | 5 days | $ 128.00 | |
10 mg | 5 days | $ 228.00 |
Description | DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway. |
In vitro | DTP3 physically interacts with MKK7 in isolation and within the complex with GADD45β, and dissociates the GADD45β/MKK7 complex via an allosteric mechanism. DTP3 selectively kills cells and induces apoptosis in MM cells with functional MKK7 and elevated GADD45β expression without toxicity to normal cells. In addition, DTP3 displays synergistic activity with bortezomib in two different MM cell lines, exhibiting a combination index of 0.56 in KMS-12 cells and of 0.21 in U266 cells. [1] |
In vivo | DTP3 treatment with 14.5 mg/kg/day exhibits potent antitumor activity against MM in mouse plasmacytoma model. [1] |
Molecular Weight | 525.6 |
Formula | C26H35N7O5 |
CAS No. | 1809784-29-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 100 mg/ml (190.26 mM)
H2O: 100 mg/ml (190.26 mM)
DMSO: 100 mg/ml (190.26 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
DTP3 1809784-29-9 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair JAK/STAT signaling Others Stem Cells DNA/RNA Synthesis JAK cancer inhibit Inhibitor Janus kinase DTP 3 NF-κB tumor GADD45β DTP-3 inhibitor