Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

EGFR-IN-1 hydrochloride

Catalog No. T11157LCas No. 2227455-78-7

EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR, with 100-fold selectivity over wild-type EGFR. It exhibits potent antitumor and antiproliferative activity in H1975 cells and mutant HCC827 cells with IC50s of 4 and 28 nM, respectively.

EGFR-IN-1 hydrochloride

EGFR-IN-1 hydrochloride

Purity: 99.8%
Catalog No. T11157LCas No. 2227455-78-7
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR, with 100-fold selectivity over wild-type EGFR. It exhibits potent antitumor and antiproliferative activity in H1975 cells and mutant HCC827 cells with IC50s of 4 and 28 nM, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$98In Stock
5 mg$256In Stock
10 mg$379In Stock
25 mg$592In Stock
50 mg$793In Stock
100 mg$1,090In Stock
500 mg$2,190In Stock
1 mL x 10 mM (in DMSO)$354In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "EGFR-IN-1 hydrochloride"

Select Batch
Purity:99.8%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR, with 100-fold selectivity over wild-type EGFR. It exhibits potent antitumor and antiproliferative activity in H1975 cells and mutant HCC827 cells with IC50s of 4 and 28 nM, respectively.
Targets&IC50
p-EGFR:4-9nM
In vitro
EGFR-IN-1 is highly selective against a panel of 100 kinases and inhibits p-EGFR in H1975 and HCC827 cells with IC50s of 4 and 9 nM, respectively[1].
In vivo
In female athymic nude mice with H1975 Tumor Xenograft, gavage administration of EGFR-IN-1 hydrochloride (30 mg/kg) significantly inhibits the tumor growth without observed loss in body weight. EGFR-IN-1 shows a >50% inhibition of phosphorylation of EGFR and a systemic exposure (AUC0-inf.) of 0.33 μM. h[1].
Chemical Properties
Molecular Weight551.04
FormulaC28H31ClN6O4
Cas No.2227455-78-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (18.15 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8148 mL9.0738 mL18.1475 mL90.7375 mL
5 mM0.3630 mL1.8148 mL3.6295 mL18.1475 mL
10 mM0.1815 mL0.9074 mL1.8148 mL9.0738 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy EGFR-IN-1 hydrochloride | purchase EGFR-IN-1 hydrochloride | EGFR-IN-1 hydrochloride cost | order EGFR-IN-1 hydrochloride | EGFR-IN-1 hydrochloride chemical structure | EGFR-IN-1 hydrochloride in vivo | EGFR-IN-1 hydrochloride in vitro | EGFR-IN-1 hydrochloride formula | EGFR-IN-1 hydrochloride molecular weight