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Eupatolide
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Catalog No. TN4038Cas No. 6750-25-0
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast cancer cells.
Eupatolide
😃Good
Catalog No. TN4038Cas No. 6750-25-0
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $297 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast cancer cells. |
| In vitro | Eupatolide exhibits potent cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines (IC50: 1.57 to 22.58 uM). Eupatolide sensitizes breast cancer cells to TRAIL through the down-regulation of c-FLIP expression. In RAW264.7 cells, Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression by inducing proteasomal degradation of TRAF6. Eupatolide suppresses PDGF-induced proliferation and migration of VSMC through HO-1 induction via ROS-Nrf2 pathway and may be a potential HO-1 inducer for preventing or treating vascular diseases[1]. |
| Molecular Weight | 248.32 |
| Formula | C15H20O3 |
| Cas No. | 6750-25-0 |
| Smiles | C=C1[C@]2([C@](OC1=O)(/C=C(\C)/CC/C=C(\C)/C[C@H]2O)[H])[H] |
| Relative Density. | 1.11 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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