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Ezatiostat hydrochloride

Catalog No. T22776 CAS 286942-97-0

Synonyms: TER199, TLK199 HCl

Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.

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Ezatiostat hydrochloride, CAS 286942-97-0

Pack Size	Availability	Price/USD
2 mg	Inquiry	$ 53.00
5 mg	Inquiry	$ 75.00
10 mg	Inquiry	$ 123.00
25 mg	Inquiry	$ 211.00
50 mg	Inquiry	$ 323.00
100 mg	Inquiry	$ 545.00
200 mg	Inquiry	$ 817.00
500 mg	Inquiry	$ 1,227.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 121.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.
In vitro	Because GST P1-1 can bind to and inhibit JNK, Ezatiostat hydrochloride has also been exhibited to inhibit GST P1-1, activate JNK, and promote the growth and maturation of hematopoietic progenitors in preclinical models. Moreover, Ezatiostat hydrochloride has been reported to stimulate the proliferation of myeloid precursors. Ezatiostat hydrochloride has been elucidated to induce growth inhibition and cellular apoptosis in human leukemia cells (CC50: 6-17μM). Apart from these, Ezatiostat hydrochloride has shown the stimulation of multilineage differentiation in mature monocytes, granulocytes, and erythrocytes [1][2].
In vivo	Administration of Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals[2].

Synonyms	TER199, TLK199 HCl
Molecular Weight	566.11
Formula	C27H36ClN3O6S
CAS No.	286942-97-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 28.3mg/mL (50.00 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ruscoe JE, et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther. 2001 Jul;298(1):339-45. 2. Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20

Related compound libraries

This product is contained In the following compound libraries：

Clinical Compound Library NO PAINS Compound Library Glutamine Metabolism Compound Library Hematonosis Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ezatiostat hydrochloride 286942-97-0 Metabolism Glutathione Peroxidase Glutathione transferases MDS lymphocyte TER 199 TER199 proliferation Ezatiostat GSTs JNK tripeptide TLK199 HCl ERK1 GSTP1 inhibit Gutathione S-transferase TLK-199 TLK 199 Apoptosis Inhibitor c-Jun TER-199 TLK199 inhibitor

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