Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | Inquiry | $ 53.00 | |
5 mg | Inquiry | $ 75.00 | |
10 mg | Inquiry | $ 123.00 | |
25 mg | Inquiry | $ 211.00 | |
50 mg | Inquiry | $ 323.00 | |
100 mg | Inquiry | $ 545.00 | |
200 mg | Inquiry | $ 817.00 | |
500 mg | Inquiry | $ 1,227.00 | |
1 mL * 10 mM (in DMSO) | Inquiry | $ 121.00 |
Description | Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1. |
In vitro | Because GST P1-1 can bind to and inhibit JNK, Ezatiostat hydrochloride has also been exhibited to inhibit GST P1-1, activate JNK, and promote the growth and maturation of hematopoietic progenitors in preclinical models. Moreover, Ezatiostat hydrochloride has been reported to stimulate the proliferation of myeloid precursors. Ezatiostat hydrochloride has been elucidated to induce growth inhibition and cellular apoptosis in human leukemia cells (CC50: 6-17μM). Apart from these, Ezatiostat hydrochloride has shown the stimulation of multilineage differentiation in mature monocytes, granulocytes, and erythrocytes [1][2]. |
In vivo | Administration of Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals[2]. |
Synonyms | TER199, TLK199 HCl |
Molecular Weight | 566.11 |
Formula | C27H36ClN3O6S |
CAS No. | 286942-97-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 28.3mg/mL (50.00 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Ezatiostat hydrochloride 286942-97-0 Metabolism Glutathione Peroxidase Glutathione transferases MDS lymphocyte TER 199 TER199 proliferation Ezatiostat GSTs JNK tripeptide TLK199 HCl ERK1 GSTP1 inhibit Gutathione S-transferase TLK-199 TLK 199 Apoptosis Inhibitor c-Jun TER-199 TLK199 inhibitor