Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 629.00 | |
50 mg | In stock | $ 896.00 | |
100 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 226.00 |
Description | FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity. |
Targets&IC50 | FLT3:0.28 nM, CDK2-CyclinA:2.47 nM, CDK6-CyclinD1:1.96 nM, CDK4-CyclinD1:0.85 nM |
In vitro | FN-1501 displays potent inhibitory activity against several tumor cells, such as MGC803, RS4;11, MCF-7, HCT-116, and NCI-H82 (GI50s of 0.37 ± 0.04, 0.05 ± 0.01, 2.84 ± 0.25, 0.09 ± 0.04, 0.11 ± 0.02 nM, respectively)[1]. |
In vivo | FN-1501 shows potent antitumor activity and it also shows little cytotoxicity on normal lymphocyte cells (LD50: 185.67 mg/kg in ICR mice). FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and obviously inhibits the growth of tumors in MV4-11-cell-inoculated-xenograft mice[1]. |
Molecular Weight | 431.49 |
Formula | C22H25N9O |
CAS No. | 1429515-59-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (104.29 mM)
You can also refer to dose conversion for different animals. More
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FN-1501 1429515-59-2 Angiogenesis Cell Cycle/Checkpoint Tyrosine Kinase/Adaptors FLT CDK FLT3 Fms like tyrosine kinase 3 Cluster of differentiation antigen 135 CD135 Cyclin dependent kinase FN1501 inhibit Inhibitor FN 1501 inhibitor