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Fondaparinux sodium

Catalog No. T4076   CAS 114870-03-0
Synonyms: Natural heparin pentasaccharide Sodium, Fondaparin sodium, SR-90107A, Arixtra

Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.

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Fondaparinux sodium Chemical Structure
Fondaparinux sodium, CAS 114870-03-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 33.00
2 mg In stock $ 46.00
5 mg In stock $ 71.00
10 mg In stock $ 129.00
25 mg In stock $ 283.00
50 mg In stock $ 492.00
100 mg In stock $ 702.00
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Purity: 98%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.
In vitro Fondaparinux sodium is the first agent of a new class of anticoagulants that selectively target factor Xa. The IC50 values of Fondaparinux(anti-Xa IU/ml) are 0.59±0.05 for activated monocytes (ac-M) and 0.17±0.03 for monocyte-derived microparticles (MMPs)[2].
In vivo Fondaparinux sodium has a linear, dose-dependent pharmacokinetic profile, which provides a highly predictable response. Fondaparinux sodium is 100% bioavailable, has a rapid onset of action, and has a half-life of 14 to 16 hours, allowing for sustained antithrombotic activity over a 24-hour period. The drug neither affects prothrombin time and activated partial thromboplastin time nor does it affect platelet function or aggregation[1].
Synonyms Natural heparin pentasaccharide Sodium, Fondaparin sodium, SR-90107A, Arixtra
Molecular Weight 1729.09
Formula C31H44N3Na10O49S8
CAS No. 114870-03-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 17.36mM

DMSO: 0.6 mM

TargetMolReferences and Literature

1. Bauer KA. et al. Fondaparinux sodium: a selective inhibitor of factor Xa. Am J Health Syst Pharm. 2001 Nov 1;58 Suppl 2:S14-7. 2. Ben-Hadj-Khalifa S, et al. Differential coagulation inhibitory effect of fondaparinux, enoxaparin and unfractionated heparin in cell models of thrombin generation. Blood Coagul Fibrinolysis. 2011 Jul;22(5):369-73.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Drug Repurposing Compound Library Inhibitor Library Bioactive Compounds Library Max

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Keywords

Fondaparinux sodium 114870-03-0 Metabolism Factor Xa inhibit Natural heparin pentasaccharide Sodium Fondaparin sodium Fxa Inhibitor Fondaparin Fondaparinux SR-90107A Arixtra inhibitor

 

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