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GR 113808

Name: GR 113808
Brand: TargetMol
SKU: T15414
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15414Cas No. 144625-51-4

Alias GR-113808

GR 113808 is a selective 5-HT4 receptor antagonist that inhibits 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT3 receptors, and attenuates dopamine release.

GR 113808

🥰Excellent

Purity: 98.16%

Catalog No. T15414Alias GR-113808Cas No. 144625-51-4

GR 113808 is a selective 5-HT4 receptor antagonist that inhibits 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT3 receptors, and attenuates dopamine release.

Pack Size	Price	Availability	Quantity
1 mg	$32	In Stock

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Purity:98.16%

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COA HNMR LCMS

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Product Introduction

Bioactivity

Description	GR 113808 is a selective 5-HT4 receptor antagonist that inhibits 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT3 receptors, and attenuates dopamine release.
In vivo	Daily administration of tegaserod increased motility in inflamed colons of guinea pigs and mice, whereas administration of GR 113808 (1 mg/kg) disrupted motility in animals without colitis[1].
Alias	GR-113808

Chemical Properties

Molecular Weight	393.5
Formula	C₁₉H₂₇N₃O₄S
Cas No.	144625-51-4
Smiles	Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (76.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5413 mL	12.7065 mL	25.4130 mL	127.0648 mL
5 mM	0.5083 mL	2.5413 mL	5.0826 mL	25.4130 mL
10 mM	0.2541 mL	1.2706 mL	2.5413 mL	12.7065 mL
20 mM	0.1271 mL	0.6353 mL	1.2706 mL	6.3532 mL
50 mM	0.0508 mL	0.2541 mL	0.5083 mL	2.5413 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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