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GR 113808

Catalog No. T15414 CAS 144625-51-4

GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 receptor (pKb= 8.8).

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GR 113808, CAS 144625-51-4

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Purity: 98%

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Description	GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 receptor (pKb= 8.8).
In vivo	GR113808 (i.p.; 1 mg/kg; 5-7 days starting 24 h after induction of colitis) displays a obviously enhance in the disease activity index which includes evaluation of weight loss, stool consistency, and presence of fecal blood [2].

Molecular Weight	393.5
Formula	C19H27N3O4S
CAS No.	144625-51-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gale JD, et al. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.Br J Pharmacol. 1994 Jan;111(1):332-8. 2. Spohn SN, et al.Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.Gastroenterology. 2016 Nov;151(5):933-944.e3.

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Keywords

GR 113808 144625-51-4 G蛋白偶联受体神经科学 5-HT Receptor Inhibitor inhibitor inhibit

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