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GR 113808

Catalog No. T15414 CAS 144625-51-4

Synonyms: GR-113808

GR 113808 is a selective 5-HT4 receptor antagonist that inhibits 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT3 receptors, and attenuates dopamine release.

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GR 113808, CAS 144625-51-4

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2 mg	In stock	$ 57.00

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Purity: 98.16%

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Chemical Properties

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Description	GR 113808 is a selective 5-HT4 receptor antagonist that inhibits 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT3 receptors, and attenuates dopamine release.
In vivo	Daily administration of tegaserod increased motility in inflamed colons of guinea pigs and mice, whereas administration of GR 113808 (1 mg/kg) disrupted motility in animals without colitis[1].

Synonyms	GR-113808
Molecular Weight	393.5
Formula	C19H27N3O4S
CAS No.	144625-51-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (76.24 mM), Sonication is recommended.

References and Literature

1. Spohn SN, et al.Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.Gastroenterology. 2016 Nov;151(5):933-944.e3. 2. Gale JD, et al. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.Br J Pharmacol. 1994 Jan;111(1):332-8.

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Org-12962 Amitriptyline Opiranserin hydrochloride Azasetron hydrochloride AS19 5-Carboxamidotryptamine maleate Trazodone Perphenazine

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GR 113808 144625-51-4 GPCR/G Protein Neuroscience 5-HT Receptor GR-113808 GR113808 inhibitor inhibit

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