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GRA Ex-25

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Purity:98.2%

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COA HNMR HPLC

GRA Ex-25

Catalog No. T3422Cas No. 307983-31-9

GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor.

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Pack Size	Price	Availability
1 mg	$57	In Stock
2 mg	$81	In Stock
5 mg	$142	In Stock
10 mg	$216	In Stock
25 mg	$441	In Stock
50 mg	$649	In Stock
100 mg	$926	In Stock
1 mL x 10 mM (in DMSO)	$196	In Stock

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Product Introduction

Bioactivity

Description	GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor.
In vitro	GRA Ex-25 binds a human glucagon receptor (h-GlucRbind) with Ki of 63 nM and a moderate glucagon induced adenylate cyclase inhibition (h-GlucRcyclase) with Ki of 254 nM under our assay conditions[1]. GRA Ex-25 has similar affinity to the rat and human glucagon receptors (IC50=56 and 55 nM, respectively)[2].
In vivo	GRA Ex-25 (3 mg/kg, i.v.) significantly reduces blood glucose which is caused by exogenous administration of glucagon in rat models. GRA Ex-25 is able to inhibit the rise in blood glucose levels elicited by exogenously administered glucagon, most likely due to the direct inhibition of glucagon stimulated hepatic glucose output[2].
Alias	GRA-Ex-25

Chemical Properties

Molecular Weight	563.61
Formula	C29H36F3N3O5
Cas No.	307983-31-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (88.71 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7743 mL	8.8714 mL	17.7428 mL	88.7138 mL
5 mM	0.3549 mL	1.7743 mL	3.5486 mL	17.7428 mL
10 mM	0.1774 mL	0.8871 mL	1.7743 mL	8.8714 mL
20 mM	0.0887 mL	0.4436 mL	0.8871 mL	4.4357 mL
50 mM	0.0355 mL	0.1774 mL	0.3549 mL	1.7743 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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