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GS-443902

Catalog No. T5539   CAS 1355149-45-9
Synonyms: SARS coronavirus, Hepatitis C virus, Remdesivir metabolite, HCV, Respiratory syncytial virus, RSV, metabolite, RdRp, RNA-dependent, GS-5734, DNA/RNA Synthesis, GS-441524, GS-441524 triphosphate, Remdesivir, SARS-CoV, GS-443902, RNA-polymerases, GS443902, Inhibitor, triphosphate, Drug Metabolite, inhibit, GS 443902

Remdesivir triphosphate is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp) with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
GS-443902, CAS 1355149-45-9
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Remdesivir triphosphate is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp) with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.
Targets&IC50 RSV RdRp:1.1 µM (IC50), HCV RdRp:5 µM (IC50)
Animal Research Cats ranged from 3.4–73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats with severe neurological and ocular FIP were not recruited. The group was started on GS-441524 at a dosage of 2.0 mg/kg SC q24h for at least 12 weeks and increased when indicated to 4.0 mg/kg SC q24h.
Synonyms SARS coronavirus, Hepatitis C virus, Remdesivir metabolite, HCV, Respiratory syncytial virus, RSV, metabolite, RdRp, RNA-dependent, GS-5734, DNA/RNA Synthesis, GS-441524, GS-441524 triphosphate, Remdesivir, SARS-CoV, GS-443902, RNA-polymerases, GS443902, Inhibitor, triphosphate, Drug Metabolite, inhibit, GS 443902
Molecular Weight 531.203
Formula C12H16N5O13P3
CAS No. 1355149-45-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Pedersen N C , Perron M , Bannasch M , et al. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis[J]. Journal of Feline Medicine & Surgery, 2019.

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